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VEGF(111): new insights in tissue invasion
Vascular endothelial growth factor is a secreted glycoprotein that acts on endothelial cells to induce developmental and physiological angiogenesis. It has also been implicated in angiogenesis occurring in several pathologies, most notably, cancer. Alternative splicing of VEGF mRNA transcripts resul...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302830/ https://www.ncbi.nlm.nih.gov/pubmed/25657624 http://dx.doi.org/10.3389/fphys.2015.00002 |
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author | Danastas, Kevin Combes, Valery Lindsay, Laura A. Grau, Georges E. R. Thompson, Michael B. Murphy, Christopher R. |
author_facet | Danastas, Kevin Combes, Valery Lindsay, Laura A. Grau, Georges E. R. Thompson, Michael B. Murphy, Christopher R. |
author_sort | Danastas, Kevin |
collection | PubMed |
description | Vascular endothelial growth factor is a secreted glycoprotein that acts on endothelial cells to induce developmental and physiological angiogenesis. It has also been implicated in angiogenesis occurring in several pathologies, most notably, cancer. Alternative splicing of VEGF mRNA transcripts results in several isoforms with distinct properties depending on their exon composition. Recently, a new isoform has been identified, VEGF(111) with a unique exon composition responsible for its high angiogenic potential. In humans, the only known inducer of VEGF(111) is DNA damage but its natural presence in the uterus of the viviparous lizard, Saiphos equalis, suggests other mechanisms of regulation. Most interestingly, the possible relationship between the evolution of viviparity and the associated increased risk in developing cancer may be important in understanding the mechanisms underlying tumor development. |
format | Online Article Text |
id | pubmed-4302830 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-43028302015-02-05 VEGF(111): new insights in tissue invasion Danastas, Kevin Combes, Valery Lindsay, Laura A. Grau, Georges E. R. Thompson, Michael B. Murphy, Christopher R. Front Physiol Physiology Vascular endothelial growth factor is a secreted glycoprotein that acts on endothelial cells to induce developmental and physiological angiogenesis. It has also been implicated in angiogenesis occurring in several pathologies, most notably, cancer. Alternative splicing of VEGF mRNA transcripts results in several isoforms with distinct properties depending on their exon composition. Recently, a new isoform has been identified, VEGF(111) with a unique exon composition responsible for its high angiogenic potential. In humans, the only known inducer of VEGF(111) is DNA damage but its natural presence in the uterus of the viviparous lizard, Saiphos equalis, suggests other mechanisms of regulation. Most interestingly, the possible relationship between the evolution of viviparity and the associated increased risk in developing cancer may be important in understanding the mechanisms underlying tumor development. Frontiers Media S.A. 2015-01-22 /pmc/articles/PMC4302830/ /pubmed/25657624 http://dx.doi.org/10.3389/fphys.2015.00002 Text en Copyright © 2015 Danastas, Combes, Lindsay, Grau, Thompson and Murphy. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Danastas, Kevin Combes, Valery Lindsay, Laura A. Grau, Georges E. R. Thompson, Michael B. Murphy, Christopher R. VEGF(111): new insights in tissue invasion |
title | VEGF(111): new insights in tissue invasion |
title_full | VEGF(111): new insights in tissue invasion |
title_fullStr | VEGF(111): new insights in tissue invasion |
title_full_unstemmed | VEGF(111): new insights in tissue invasion |
title_short | VEGF(111): new insights in tissue invasion |
title_sort | vegf(111): new insights in tissue invasion |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302830/ https://www.ncbi.nlm.nih.gov/pubmed/25657624 http://dx.doi.org/10.3389/fphys.2015.00002 |
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