Cargando…

The UNC-6/Netrin receptors UNC-40/DCC and UNC-5 inhibit growth cone filopodial protrusion via UNC-73/Trio, Rac-like GTPases and UNC-33/CRMP

UNC-6/Netrin is a conserved axon guidance cue that can mediate both attraction and repulsion. We previously discovered that attractive UNC-40/DCC receptor signaling stimulates growth cone filopodial protrusion and that repulsive UNC-40–UNC-5 heterodimers inhibit filopodial protrusion in C. elegans....

Descripción completa

Detalles Bibliográficos
Autores principales:	Norris, Adam D., Sundararajan, Lakshmi, Morgan, Dyan E., Roberts, Zachary J., Lundquist, Erik A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302909/ https://www.ncbi.nlm.nih.gov/pubmed/25371370 http://dx.doi.org/10.1242/dev.110437

Ejemplares similares

UNC-6 (netrin) stabilizes oscillatory clustering of the UNC-40 (DCC) receptor to orient polarity
por: Wang, Zheng, et al.
Publicado: (2014)

TOM-1/tomosyn acts with the UNC-6/netrin receptor UNC-5 to inhibit growth cone protrusion in Caenorhabditis elegans
por: Mahadik, Snehal S., et al.
Publicado: (2023)

Experimental evidence for UNC-6 (netrin) axon guidance by stochastic fluctuations of intracellular UNC-40 (DCC) outgrowth activity
por: Kulkarni, Gauri, et al.
Publicado: (2013)

Extracellular Matrix Regulates UNC-6 (Netrin) Axon Guidance by Controlling the Direction of Intracellular UNC-40 (DCC) Outgrowth Activity
por: Yang, Yong, et al.
Publicado: (2014)

A short isoform of the UNC-6/Netrin receptor UNC-5 is required for growth cone polarity and robust growth cone protrusion in Caenorhabditis elegans
por: Mahadik, Snehal S., et al.
Publicado: (2023)

A short isoform of the UNC-6/Netrin receptor UNC-5 is required for growth cone polarity and robust growth cone protrusion in Caenorhabditis elegans
por: Mahadik, Snehal S., et al.
Publicado: (2023)

Flavin monooxygenases regulate Caenorhabditis elegans axon guidance and growth cone protrusion with UNC-6/Netrin signaling and Rac GTPases
por: Gujar, Mahekta R., et al.
Publicado: (2017)

UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways
por: MacNeil, Lesley T., et al.
Publicado: (2009)

A Systematic Analysis of the Role of Unc-5 Netrin Receptor A (UNC5A) in Human Cancers
por: Zhou, Zonglang, et al.
Publicado: (2022)

Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons
por: Meng, Lingfeng, et al.
Publicado: (2016)

Netrin (UNC-6) mediates dendritic self-avoidance
por: Smith, Cody J., et al.
Publicado: (2012)

UNC-116 and UNC-16 function with the NEKL-3 kinase to promote axon targeting
por: Drozd, Cody J., et al.
Publicado: (2023)

The Rac GTP Exchange Factor TIAM-1 Acts with CDC-42 and the Guidance Receptor UNC-40/DCC in Neuronal Protrusion and Axon Guidance
por: Demarco, Rafael S., et al.
Publicado: (2012)

Selecting synaptic partners: GRASPing the role of UNC-6/netrin
por: Ch'ng, QueeLim
Publicado: (2011)

Two alleles of unc-52 locus disrupting potential cell-binding motif of UNC-52
por: Wilsey, Rachel, et al.
Publicado: (2020)

unc-119 mutants have an increased fungal spore adhesion that is not rescued by Cb-unc-119
por: Omi, Shizue, et al.
Publicado: (2021)

Unc13A and Unc13B contribute to the decoding of distinct sensory information in Drosophila
por: Pooryasin, Atefeh, et al.
Publicado: (2021)

Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complex
por: Kang, Yunlu, et al.
Publicado: (2022)

Expression and Relationship of Netrin-1, DCC, UNC5B, and VEGF in Villous Tissues of Patients with Delayed Abortion
por: Dong, Fen, et al.
Publicado: (2022)

The Caenorhabditis elegans voltage-gated calcium channel subunits UNC-2 and UNC-36 and the calcium-dependent kinase UNC-43/CaMKII regulate neuromuscular junction morphology
por: Caylor, Raymond C, et al.
Publicado: (2013)

The Arp2/3 complex, UNC-115/abLIM, and UNC-34/Enabled regulate axon guidance and growth cone filopodia formation in Caenorhabditis elegans
por: Norris, Adam D, et al.
Publicado: (2009)

Cooperation Achieves Results at UNC-CH
por: Eubanks, Mary
Publicado: (2004)

Breathing down the neck of Unc104
por: Wordeman, Linda
Publicado: (2003)

The netrin receptor UNC-40/DCC assembles a postsynaptic scaffold and sets the synaptic content of GABA(A) receptors
por: Zhou, Xin, et al.
Publicado: (2020)

Retracted: Expression and Relationship of Netrin-1, DCC, UNC5B, and VEGF in Villous Tissues of Patients with Delayed Abortion
por: Imaging, Contrast Media & Molecular
Publicado: (2023)

UNC-6 (Netrin) Orients the Invasive Membrane of the Anchor Cell in C. elegans
por: Ziel, Joshua W., et al.
Publicado: (2008)

Molecular characterization of the netrin-1 UNC-5 receptor in Lucilia sericata larvae
por: Karamzadeh, Tahereh, et al.
Publicado: (2019)

Expanding the Vision of Environmental Health at UNC-CH
por: Spivey, Angela
Publicado: (2004)

NIEHS, UNC and Duke Instate Training Program
Publicado: (1994)

Interactions between innexins UNC-7 and UNC-9 mediate electrical synapse specificity in the Caenorhabditis elegans locomotory nervous system
por: Starich, Todd A, et al.
Publicado: (2009)

UNC-13L, UNC-13S, and Tomosyn form a protein code for fast and slow neurotransmitter release in Caenorhabditis elegans
por: Hu, Zhitao, et al.
Publicado: (2013)

Netrin-1 binding to Unc5B regulates Blood-Retina Barrier integrity
por: Furtado, Jessica, et al.
Publicado: (2023)

RACK-1 Acts with Rac GTPase Signaling and UNC-115/abLIM in Caenorhabditis elegans Axon Pathfinding and Cell Migration
por: Demarco, Rafael S., et al.
Publicado: (2010)

Synaptic Protein Degradation Controls Sexually Dimorphic Circuits through Regulation of DCC/UNC-40
por: Salzberg, Yehuda, et al.
Publicado: (2020)

unc-33/CRMP and ankyrin organize microtubules and localize kinesin to polarize axon-dendrite sorting
por: Maniar, Tapan A., et al.
Publicado: (2011)

CRMP/UNC-33 organizes microtubule bundles for KIF5-mediated mitochondrial distribution to axon
por: Chen, Ying-Chun, et al.
Publicado: (2021)

UNC79 and UNC80, Putative Auxiliary Subunits of the NARROW ABDOMEN Ion Channel, Are Indispensable for Robust Circadian Locomotor Rhythms in Drosophila
por: Lear, Bridget C., et al.
Publicado: (2013)

Unc-5 homolog B (UNC5B) is one of the key downstream targets of N-α-Acetyltransferase 10 (Naa10)
por: Xu, Huiyu, et al.
Publicado: (2016)

UNC-33L partially rescues life span and locomotion defects in unc-33 mutants but fails to rescue dauer formation defects.
por: Lopez, Melissa E, et al.
Publicado: (2022)

RHO-1 and the Rho GEF RHGF-1 interact with UNC-6/Netrin signaling to regulate growth cone protrusion and microtubule organization in Caenorhabditis elegans
por: Gujar, Mahekta R., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_tpoc6v6ch7ba2c28mfn1ff2rvo