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Intestinal tumor suppression in Apc(Min/+) mice by prostaglandin D(2) receptor PTGDR

Our earlier work showed that knockout of hematopoietic prostaglandin D synthase (HPGDS, an enzyme that produces prostaglandin D(2)) caused more adenomas in Apc(Min/+) mice. Conversely, highly expressed transgenic HPGDS allowed fewer tumors. Prostaglandin D(2) (PGD(2)) binds to the prostaglandin D(2)...

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Detalles Bibliográficos
Autores principales:	Tippin, Brigette L, Kwong, Alan M, Inadomi, Michael J, Lee, Oliver J, Park, Jae Man, Materi, Alicia M, Buslon, Virgilio S, Lin, Amy M, Kudo, Lili C, Karsten, Stanislav L, French, Samuel W, Narumiya, Shuh, Urade, Yoshihiro, Salido, Eduardo, Lin, Henry J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Cancer Prevention
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303173/ https://www.ncbi.nlm.nih.gov/pubmed/24729479 http://dx.doi.org/10.1002/cam4.251

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