Insulin-like growth factor-I inhibition with pasireotide decreases cell proliferation and increases apoptosis in pre-malignant lesions of the breast: a phase 1 proof of principle trial

INTRODUCTION: Estrogen inhibition is effective in preventing breast cancer in only up to 50% of women with precancerous lesions and many experience side effects that are poorly tolerated. As insulin-like growth factor I (IGF-I) underlies both estrogen and progesterone actions and has other direct ef...

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Detalles Bibliográficos
Autores principales: Singh, Baljit, Smith, Julia A, Axelrod, Deborah M, Ameri, Pietro, Levitt, Heather, Danoff, Ann, Lesser, Martin, de Angelis, Cristina, Illa-Bochaca, Irineu, Lubitz, Sara, Huberman, Daniel, Darvishian, Farbod, Kleinberg, David L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303192/
https://www.ncbi.nlm.nih.gov/pubmed/25385439
http://dx.doi.org/10.1186/s13058-014-0463-1

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