Progesterone receptor activation downregulates GATA3 by transcriptional repression and increased protein turnover promoting breast tumor growth

INTRODUCTION: The transcription factor GATA3 is involved in mammary gland development and is crucial for the maintenance of the differentiated status of luminal epithelial cells. The role of GATA3 in breast cancer as a tumor suppressor has been established, although insights into the mechanism of GA...

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Detalles Bibliográficos
Autores principales: Izzo, Franco, Mercogliano, Florencia, Venturutti, Leandro, Tkach, Mercedes, Inurrigarro, Gloria, Schillaci, Roxana, Cerchietti, Leandro, Elizalde, Patricia V, Proietti, Cecilia J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303201/
https://www.ncbi.nlm.nih.gov/pubmed/25479686
http://dx.doi.org/10.1186/s13058-014-0491-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303201/
https://www.ncbi.nlm.nih.gov/pubmed/25479686
http://dx.doi.org/10.1186/s13058-014-0491-x

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