A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes

INTRODUCTION: The activation of the phosphoinositide 3-kinase (PI3K)/AKT signalling pathway is one the most frequent genetic events in breast cancer, consequently the development of PI3K inhibitors has attracted much attention. Here we evaluate the effect of PI3K inhibition on global gene expression...

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Detalles Bibliográficos
Autores principales: Hill, Richard, Kalathur, Ravi Kiran Reddy, Callejas, Sergio, Colaço, Laura, Brandão, Ricardo, Serelde, Beatriz, Cebriá, Antonio, Blanco-Aparicio, Carmen, Pastor, Joaquín, Futschik, Matthias, Dopazo, Ana, Link, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303209/
https://www.ncbi.nlm.nih.gov/pubmed/25488803
http://dx.doi.org/10.1186/s13058-014-0482-y

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