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Physical activity and telomere length in early stage breast cancer survivors
INTRODUCTION: Telomere length (TL) is a biomarker of accumulated cellular damage and human aging. Evidence in healthy populations suggests that TL is impacted by a host of psychosocial and lifestyle factors, including physical activity. This is the first study to evaluate the relationship between se...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303228/ https://www.ncbi.nlm.nih.gov/pubmed/25074648 http://dx.doi.org/10.1186/s13058-014-0413-y |
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author | Garland, Sheila N Johnson, Brad Palmer, Christina Speck, Rebecca M Donelson, Michelle Xie, Sharon X DeMichele, Angela Mao, Jun J |
author_facet | Garland, Sheila N Johnson, Brad Palmer, Christina Speck, Rebecca M Donelson, Michelle Xie, Sharon X DeMichele, Angela Mao, Jun J |
author_sort | Garland, Sheila N |
collection | PubMed |
description | INTRODUCTION: Telomere length (TL) is a biomarker of accumulated cellular damage and human aging. Evidence in healthy populations suggests that TL is impacted by a host of psychosocial and lifestyle factors, including physical activity. This is the first study to evaluate the relationship between self-reported physical activity and telomere length in early stage breast cancer survivors. METHODS: A cross-sectional sample of 392 postmenopausal women with stage I-III breast cancer at an outpatient oncology clinic of a large university hospital completed questionnaires and provided a blood sample. TL was determined using terminal restriction fragment length analysis of genomic DNA isolated from peripheral blood mononuclear cells. Physical activity was dichotomized into two groups (none versus moderate to vigorous) using the International Physical Activity Questionnaire. Multivariate linear and logistic regression analyses were performed to identify factors associated with mean TL and physical activity. RESULTS: Among participants, 66 (17%) did not participate in any physical activity. In multivariate model adjusted for age, compared to those who participated in moderate to vigorous physical activity, women who participated in no physical activity had significantly shorter TL (adjusted coefficient β = −0.22; 95% confidence interval (CI), −0.41 to −0.03; P = .03). Non-white race, lower education and depressive symptoms were associated with lack of self-reported physical activity (P < 0.05 for all) but not TL. CONCLUSION: Lack of physical activity is associated with shortened TL, warranting prospective investigation of the potential role of physical activity on cellular aging in breast cancer survivors. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13058-014-0413-y) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4303228 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43032282015-01-23 Physical activity and telomere length in early stage breast cancer survivors Garland, Sheila N Johnson, Brad Palmer, Christina Speck, Rebecca M Donelson, Michelle Xie, Sharon X DeMichele, Angela Mao, Jun J Breast Cancer Res Research Article INTRODUCTION: Telomere length (TL) is a biomarker of accumulated cellular damage and human aging. Evidence in healthy populations suggests that TL is impacted by a host of psychosocial and lifestyle factors, including physical activity. This is the first study to evaluate the relationship between self-reported physical activity and telomere length in early stage breast cancer survivors. METHODS: A cross-sectional sample of 392 postmenopausal women with stage I-III breast cancer at an outpatient oncology clinic of a large university hospital completed questionnaires and provided a blood sample. TL was determined using terminal restriction fragment length analysis of genomic DNA isolated from peripheral blood mononuclear cells. Physical activity was dichotomized into two groups (none versus moderate to vigorous) using the International Physical Activity Questionnaire. Multivariate linear and logistic regression analyses were performed to identify factors associated with mean TL and physical activity. RESULTS: Among participants, 66 (17%) did not participate in any physical activity. In multivariate model adjusted for age, compared to those who participated in moderate to vigorous physical activity, women who participated in no physical activity had significantly shorter TL (adjusted coefficient β = −0.22; 95% confidence interval (CI), −0.41 to −0.03; P = .03). Non-white race, lower education and depressive symptoms were associated with lack of self-reported physical activity (P < 0.05 for all) but not TL. CONCLUSION: Lack of physical activity is associated with shortened TL, warranting prospective investigation of the potential role of physical activity on cellular aging in breast cancer survivors. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13058-014-0413-y) contains supplementary material, which is available to authorized users. BioMed Central 2014-07-31 2014 /pmc/articles/PMC4303228/ /pubmed/25074648 http://dx.doi.org/10.1186/s13058-014-0413-y Text en © Garland et al.; licensee BioMed Central 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Garland, Sheila N Johnson, Brad Palmer, Christina Speck, Rebecca M Donelson, Michelle Xie, Sharon X DeMichele, Angela Mao, Jun J Physical activity and telomere length in early stage breast cancer survivors |
title | Physical activity and telomere length in early stage breast cancer survivors |
title_full | Physical activity and telomere length in early stage breast cancer survivors |
title_fullStr | Physical activity and telomere length in early stage breast cancer survivors |
title_full_unstemmed | Physical activity and telomere length in early stage breast cancer survivors |
title_short | Physical activity and telomere length in early stage breast cancer survivors |
title_sort | physical activity and telomere length in early stage breast cancer survivors |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303228/ https://www.ncbi.nlm.nih.gov/pubmed/25074648 http://dx.doi.org/10.1186/s13058-014-0413-y |
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