Cargando…

Polymerase and Exonuclease Activities in Herpes Simplex Virus Type 1 DNA Polymerase Are Not Highly Coordinated

[Image: see text] The herpes polymerase–processivity factor complex consists of the catalytic UL30 subunit containing both polymerase and proofreading exonuclease activities and the UL42 subunit that acts as a processivity factor. Curiously, the highly active exonuclease has minimal impact on the ac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vashishtha, Ashwani Kumar, Kuchta, Robert D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303300/ https://www.ncbi.nlm.nih.gov/pubmed/25517265 http://dx.doi.org/10.1021/bi500840v

Ejemplares similares

Assessing the contribution of the herpes simplex virus DNA polymerase to spontaneous mutations
por: Duffy, Karen E, et al.
Publicado: (2002)

Switching between polymerase and exonuclease sites in DNA polymerase ε
por: Ganai, Rais A., et al.
Publicado: (2015)

Kinetic Approaches to Understanding the Mechanisms of Fidelity of the Herpes Simplex Virus Type 1 DNA Polymerase
por: Zhu, Yali, et al.
Publicado: (2010)

Manipulation of RNA polymerase III by Herpes Simplex Virus-1
por: Dremel, Sarah E., et al.
Publicado: (2022)

Noncanonical prokaryotic X family DNA polymerases lack polymerase activity and act as exonucleases
por: Prostova, Maria, et al.
Publicado: (2022)

The effect of different divalent cations on the kinetics and fidelity of Bacillus stearothermophilus DNA polymerase
por: Vashishtha, Ashwani Kumar, et al.
Publicado: (2018)

New insights into the coordination between the polymerization and 3′-5′ exonuclease activities in ϕ29 DNA polymerase
por: del Prado, Alicia, et al.
Publicado: (2019)

Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies
por: Bratic, Ana, et al.
Publicado: (2015)

The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication
por: Macao, Bertil, et al.
Publicado: (2015)

DNA polymerase ɛ and δ exonuclease domain mutations in endometrial cancer
por: Church, David N., et al.
Publicado: (2013)

Reduced structural flexibility for an exonuclease deficient DNA polymerase III mutant†
por: Gahlon, Hailey L., et al.
Publicado: (2018)

Trypanosoma brucei Mitochondrial DNA Polymerase POLIB Contains a Novel Polymerase Domain Insertion That Confers Dominant Exonuclease Activity
por: Delzell, Stephanie B., et al.
Publicado: (2022)

Comparative Analysis of Polymerase Chain Reaction Assay for Herpes Simplex Virus 1 Detection in Tear
por: Lee, Seung Yong, et al.
Publicado: (2013)

Herpes Simplex Virus 1 and 2 in Herpes Genitalis: A Polymerase Chain Reaction-Based Study from Kerala
por: Mathew, Rani, et al.
Publicado: (2018)

Variant Analysis of the Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus in Korea: Frequency of Acyclovir Resistance Mutations
por: Hyun, Jungwon, et al.
Publicado: (2023)

Exonuclease processivity of archaeal replicative DNA polymerase in association with PCNA is expedited by mismatches in DNA
por: Yoda, Takuya, et al.
Publicado: (2017)

Evidence for interplay among yeast replicative DNA polymerases alpha, delta and epsilon from studies of exonuclease and polymerase active site mutations
por: Pavlov, Youri I, et al.
Publicado: (2004)

Evolution of DNA polymerases: an inactivated polymerase-exonuclease module in Pol ε and a chimeric origin of eukaryotic polymerases from two classes of archaeal ancestors
por: Tahirov, Tahir H, et al.
Publicado: (2009)

Proofreading exonuclease activity of human DNA polymerase δ and its effects on lesion-bypass DNA synthesis
por: Fazlieva, Ruzaliya, et al.
Publicado: (2009)

Correction: Evidence for interplay among yeast replicative DNA polymerases alpha, delta and epsilon from studies of exonuclease and polymerase active site mutations
por: Pavlov, Youri I, et al.
Publicado: (2007)

DNA stabilization at the Bacillus subtilis PolX core—a binding model to coordinate polymerase, AP-endonuclease and 3′-5′ exonuclease activities
por: Baños, Benito, et al.
Publicado: (2012)

Characterization of hotspot exonuclease domain mutations in the DNA polymerase ϵ gene in endometrial cancer
por: Tian, Wenjuan, et al.
Publicado: (2022)

Human cytomegalovirus and Herpes Simplex type I virus can engage RNA polymerase I for transcription of immediate early genes
por: Kostopoulou, Ourania N., et al.
Publicado: (2017)

A case of herpes simplex keratouveitis diagnosed by real time polymerase chain reaction
por: Gondchawar, Ankush, et al.
Publicado: (2015)

Significant contribution of the 3′→5′ exonuclease activity to the high fidelity of nucleotide incorporation catalyzed by human DNA polymerase ϵ
por: Zahurancik, Walter J., et al.
Publicado: (2014)

Whole Blood Polymerase Chain Reaction in a Neonate with Disseminated Herpes Simplex Virus Infection and Liver Failure
por: Scoble, Jennifer A., et al.
Publicado: (2013)

The proofreading exonuclease subunit ε of Escherichia coli DNA polymerase III is tethered to the polymerase subunit α via a flexible linker
por: Ozawa, Kiyoshi, et al.
Publicado: (2008)

Exploration of factors driving incorporation of unnatural dNTPS into DNA by Klenow fragment (DNA polymerase I) and DNA polymerase α
por: Kincaid, Kristi, et al.
Publicado: (2005)

A Fatal Case of Herpes Simplex Encephalitis with Two False-Negative Polymerase Chain Reactions
por: Mendez, Aldo A., et al.
Publicado: (2018)

Non-nucleosidic inhibition of Herpes simplex virus DNA polymerase: mechanistic insights into the anti-herpetic mode of action of herbal drug withaferin A
por: Grover, Abhinav, et al.
Publicado: (2011)

Symmetric activity of DNA polymerases at and recruitment of exonuclease ExoR and of PolA to the Bacillus subtilis replication forks
por: Hernández-Tamayo, Rogelio, et al.
Publicado: (2019)

A Protracted Course of Herpes Simplex Virus Type 1 Encephalitis With Persistent Cerebrospinal Fluid Polymerase Chain Reaction Positivity Post Treatment
por: Abbott, Andrew, et al.
Publicado: (2021)

The herpes simplex virus type 1 DNA polymerase processivity factor, UL42, does not alter the catalytic activity of the UL9 origin-binding protein but facilitates its loading onto DNA
por: Trego, Kelly S., et al.
Publicado: (2005)

The TREX2 3′→ 5′ Exonuclease Physically Interacts with DNA Polymerase δ and Increases Its Accuracy
por: Shevelev, Igor V., et al.
Publicado: (2002)

Kinetics of DNA strand transfer between polymerase and proofreading exonuclease active sites regulates error correction during high-fidelity replication
por: Dangerfield, Tyler L., et al.
Publicado: (2022)

Preferential Inhibition of Herpes-Group Viruses by Phosphonoacetic Acid: Effect on Virus DNA Synthesis and Virus-Induced DNA Polymerase Activity
por: Huang, Eng-Shang, et al.
Publicado: (1976)

Herpes Simplex Virus Type 2 Is More Difficult to Neutralize by Antibodies Than Herpes Simplex Virus Type 1
por: Silke Heilingloh, Christiane, et al.
Publicado: (2020)

Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication
por: Shinbrot, Eve, et al.
Publicado: (2014)

Kinetic Characterization of Exonuclease-Deficient Staphylococcus aureus PolC, a C-family Replicative DNA Polymerase
por: Lahiri, Indrajit, et al.
Publicado: (2013)

Delayed Diagnosis of Tuberculous Meningitis Misdiagnosed as Herpes Simplex Virus-1 Encephalitis With the FilmArray Syndromic Polymerase Chain Reaction Panel
por: Gomez, Carlos A., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_kmbnn4qp6e2fb5lakvqc06acbm