Defective Hydrophobic Sliding Mechanism and Active Site Expansion in HIV-1 Protease Drug Resistant Variant Gly48Thr/Leu89Met: Mechanisms for the Loss of Saquinavir Binding Potency

[Image: see text] HIV drug resistance continues to emerge; consequently, there is an urgent need to develop next generation antiretroviral therapeutics.1 Here we report on the structural and kinetic effects of an HIV protease drug resistant variant with the double mutations Gly48Thr and Leu89Met (PR...

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Detalles Bibliográficos
Autores principales: Goldfarb, Nathan E., Ohanessian, Meray, Biswas, Shyamasri, McGee, T. Dwight, Mahon, Brian P., Ostrov, David A., Garcia, Jose, Tang, Yan, McKenna, Robert, Roitberg, Adrian, Dunn, Ben M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303317/
https://www.ncbi.nlm.nih.gov/pubmed/25513833
http://dx.doi.org/10.1021/bi501088e

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