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Physicochemical and biological properties of a novel injectable polyurethane system for root canal filling
A root canal sealer with antibacterial activity can be efficacious in preventing reinfection that results from residual microorganisms and/or the leakage of microorganisms. In the present study, a series of injectable, self-curing polyurethane (PU)-based antibacterial sealers with different concentr...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303460/ https://www.ncbi.nlm.nih.gov/pubmed/25653518 http://dx.doi.org/10.2147/IJN.S74025 |
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author | Wang, Jian Zuo, Yi Zhao, Minghui Jiang, Jiaxing Man, Yi Wu, Jun Hu, Yunjiu Liu, Changlei Li, Yubao Li, Jidong |
author_facet | Wang, Jian Zuo, Yi Zhao, Minghui Jiang, Jiaxing Man, Yi Wu, Jun Hu, Yunjiu Liu, Changlei Li, Yubao Li, Jidong |
author_sort | Wang, Jian |
collection | PubMed |
description | A root canal sealer with antibacterial activity can be efficacious in preventing reinfection that results from residual microorganisms and/or the leakage of microorganisms. In the present study, a series of injectable, self-curing polyurethane (PU)-based antibacterial sealers with different concentrations of silver phosphate (Ag(3)PO(4)) were fabricated. Subsequently, their physicochemical properties, antibacterial abilities, and preliminary cytocompatibilities were evaluated. The results indicated that the fabricated PU-based sealers can achieve a high conversion rate in a short amount of time. More than 95% of the isocyanate group of PU sealers with 3 wt% (PU3) and 5 wt% (PU5) concentrations of Ag(3)PO(4) were included in the curing reaction after 7 hours. With the exception of those for film thickness for PU5, the results of setting time, film thickness, and solubility were able to meet the requirements of the International Organization for Standardization. The antibacterial tests showed that PU3 and PU5 exhibit stronger antimicrobial effects than that achieved with 1 wt% Ag(3)PO(4) (PU1) and AH Plus (positive control) against Streptococcus mutans. The cytocompatibility evaluation revealed that the PU1 and PU3 sealers possess good cytocompatibility and low cytotoxicity. These results demonstrate that the PU3 sealer offers good physicochemical and antimicrobial properties along with cytocompatibility, which may hold great application potential in the field of root canal fillings. |
format | Online Article Text |
id | pubmed-4303460 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-43034602015-02-04 Physicochemical and biological properties of a novel injectable polyurethane system for root canal filling Wang, Jian Zuo, Yi Zhao, Minghui Jiang, Jiaxing Man, Yi Wu, Jun Hu, Yunjiu Liu, Changlei Li, Yubao Li, Jidong Int J Nanomedicine Original Research A root canal sealer with antibacterial activity can be efficacious in preventing reinfection that results from residual microorganisms and/or the leakage of microorganisms. In the present study, a series of injectable, self-curing polyurethane (PU)-based antibacterial sealers with different concentrations of silver phosphate (Ag(3)PO(4)) were fabricated. Subsequently, their physicochemical properties, antibacterial abilities, and preliminary cytocompatibilities were evaluated. The results indicated that the fabricated PU-based sealers can achieve a high conversion rate in a short amount of time. More than 95% of the isocyanate group of PU sealers with 3 wt% (PU3) and 5 wt% (PU5) concentrations of Ag(3)PO(4) were included in the curing reaction after 7 hours. With the exception of those for film thickness for PU5, the results of setting time, film thickness, and solubility were able to meet the requirements of the International Organization for Standardization. The antibacterial tests showed that PU3 and PU5 exhibit stronger antimicrobial effects than that achieved with 1 wt% Ag(3)PO(4) (PU1) and AH Plus (positive control) against Streptococcus mutans. The cytocompatibility evaluation revealed that the PU1 and PU3 sealers possess good cytocompatibility and low cytotoxicity. These results demonstrate that the PU3 sealer offers good physicochemical and antimicrobial properties along with cytocompatibility, which may hold great application potential in the field of root canal fillings. Dove Medical Press 2015-01-17 /pmc/articles/PMC4303460/ /pubmed/25653518 http://dx.doi.org/10.2147/IJN.S74025 Text en © 2015 Wang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Wang, Jian Zuo, Yi Zhao, Minghui Jiang, Jiaxing Man, Yi Wu, Jun Hu, Yunjiu Liu, Changlei Li, Yubao Li, Jidong Physicochemical and biological properties of a novel injectable polyurethane system for root canal filling |
title | Physicochemical and biological properties of a novel injectable polyurethane system for root canal filling |
title_full | Physicochemical and biological properties of a novel injectable polyurethane system for root canal filling |
title_fullStr | Physicochemical and biological properties of a novel injectable polyurethane system for root canal filling |
title_full_unstemmed | Physicochemical and biological properties of a novel injectable polyurethane system for root canal filling |
title_short | Physicochemical and biological properties of a novel injectable polyurethane system for root canal filling |
title_sort | physicochemical and biological properties of a novel injectable polyurethane system for root canal filling |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303460/ https://www.ncbi.nlm.nih.gov/pubmed/25653518 http://dx.doi.org/10.2147/IJN.S74025 |
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