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All the world’s a (clinical) stage: Rethinking bipolar disorder from a longitudinal perspective
Psychiatric disorders have traditionally been classified using a static, categorical approach. However, this approach falls short in facilitating understanding of the development, common comorbid diagnoses, prognosis, and treatment of these disorders. We propose a “staging” model of bipolar disorder...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303542/ https://www.ncbi.nlm.nih.gov/pubmed/25048003 http://dx.doi.org/10.1038/mp.2014.71 |
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author | Frank, Ellen Nimgaonkar, Vishwajit L. Phillips, Mary L. Kupfer, David J. |
author_facet | Frank, Ellen Nimgaonkar, Vishwajit L. Phillips, Mary L. Kupfer, David J. |
author_sort | Frank, Ellen |
collection | PubMed |
description | Psychiatric disorders have traditionally been classified using a static, categorical approach. However, this approach falls short in facilitating understanding of the development, common comorbid diagnoses, prognosis, and treatment of these disorders. We propose a “staging” model of bipolar disorder that integrates genetic and neural information with mood and activity symptoms to describe how the disease progresses over time. From an early, asymptomatic, but “at risk” stage to severe, chronic illness, each stage is described with associated neuroimaging findings as well as strategies for mapping genetic risk factors. Integrating more biologic information relating to cardiovascular and endocrine systems, refining methodology for modeling dimensional approaches to disease, and developing outcome measures will all be crucial in examining the validity of this model. Ultimately, this approach should aid in developing targeted interventions for each group that will reduce the significant morbidity and mortality associated with bipolar disorder. |
format | Online Article Text |
id | pubmed-4303542 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
record_format | MEDLINE/PubMed |
spelling | pubmed-43035422015-08-01 All the world’s a (clinical) stage: Rethinking bipolar disorder from a longitudinal perspective Frank, Ellen Nimgaonkar, Vishwajit L. Phillips, Mary L. Kupfer, David J. Mol Psychiatry Article Psychiatric disorders have traditionally been classified using a static, categorical approach. However, this approach falls short in facilitating understanding of the development, common comorbid diagnoses, prognosis, and treatment of these disorders. We propose a “staging” model of bipolar disorder that integrates genetic and neural information with mood and activity symptoms to describe how the disease progresses over time. From an early, asymptomatic, but “at risk” stage to severe, chronic illness, each stage is described with associated neuroimaging findings as well as strategies for mapping genetic risk factors. Integrating more biologic information relating to cardiovascular and endocrine systems, refining methodology for modeling dimensional approaches to disease, and developing outcome measures will all be crucial in examining the validity of this model. Ultimately, this approach should aid in developing targeted interventions for each group that will reduce the significant morbidity and mortality associated with bipolar disorder. 2014-07-22 2015-02 /pmc/articles/PMC4303542/ /pubmed/25048003 http://dx.doi.org/10.1038/mp.2014.71 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Frank, Ellen Nimgaonkar, Vishwajit L. Phillips, Mary L. Kupfer, David J. All the world’s a (clinical) stage: Rethinking bipolar disorder from a longitudinal perspective |
title | All the world’s a (clinical) stage: Rethinking bipolar disorder from a longitudinal perspective |
title_full | All the world’s a (clinical) stage: Rethinking bipolar disorder from a longitudinal perspective |
title_fullStr | All the world’s a (clinical) stage: Rethinking bipolar disorder from a longitudinal perspective |
title_full_unstemmed | All the world’s a (clinical) stage: Rethinking bipolar disorder from a longitudinal perspective |
title_short | All the world’s a (clinical) stage: Rethinking bipolar disorder from a longitudinal perspective |
title_sort | all the world’s a (clinical) stage: rethinking bipolar disorder from a longitudinal perspective |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303542/ https://www.ncbi.nlm.nih.gov/pubmed/25048003 http://dx.doi.org/10.1038/mp.2014.71 |
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