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Biosynthesis of fosfazinomycin is a convergent process
Fosfazinomycin A is a phosphonate natural product in which the C-terminal carboxylate of a Val–Arg dipeptide is connected to methyl 2-hydroxy-2-phosphono-acetate (Me-HPnA) via a unique hydrazide linkage. We report here that Me-HPnA is generated from phosphonoacetaldehyde (PnAA) in three biosynthetic...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303578/ https://www.ncbi.nlm.nih.gov/pubmed/25621145 http://dx.doi.org/10.1039/c4sc03095h |