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Identification and Pharmacological Inactivation of the MYCN Gene Network as a Therapeutic Strategy for Neuroblastic Tumor Cells

The MYC family of transcription factors consists of three well characterized members, c-MYC, L-MYC, and MYCN, deregulated in the majority of human cancers. In neuronal tumors such as neuroblastoma, MYCN is frequently activated by gene amplification, and reducing its expression by RNA interference ha...

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Detalles Bibliográficos
Autores principales:	Chayka, Olesya, D'Acunto, Cosimo Walter, Middleton, Odette, Arab, Maryam, Sala, Arturo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2015
Materias:	Genomics and Proteomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303671/ https://www.ncbi.nlm.nih.gov/pubmed/25477524 http://dx.doi.org/10.1074/jbc.M114.624056

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