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Increased Circulating Levels of Vitamin D Binding Protein in MS Patients

Vitamin D (vitD) low status is currently considered a main environmental factor in multiple sclerosis (MS) etiology and pathogenesis. VitD and its metabolites are highly hydrophobic and circulate mostly bound to the vitamin D binding protein (DBP) and with lower affinity to albumin, while less than...

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Autores principales: Rinaldi, Arturo Ottavio, Sanseverino, Isabella, Purificato, Cristina, Cortese, Antonio, Mechelli, Rosella, Francisci, Silvia, Salvetti, Marco, Millefiorini, Enrico, Gessani, Sandra, Gauzzi, Maria Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303818/
https://www.ncbi.nlm.nih.gov/pubmed/25590278
http://dx.doi.org/10.3390/toxins7010129
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author Rinaldi, Arturo Ottavio
Sanseverino, Isabella
Purificato, Cristina
Cortese, Antonio
Mechelli, Rosella
Francisci, Silvia
Salvetti, Marco
Millefiorini, Enrico
Gessani, Sandra
Gauzzi, Maria Cristina
author_facet Rinaldi, Arturo Ottavio
Sanseverino, Isabella
Purificato, Cristina
Cortese, Antonio
Mechelli, Rosella
Francisci, Silvia
Salvetti, Marco
Millefiorini, Enrico
Gessani, Sandra
Gauzzi, Maria Cristina
author_sort Rinaldi, Arturo Ottavio
collection PubMed
description Vitamin D (vitD) low status is currently considered a main environmental factor in multiple sclerosis (MS) etiology and pathogenesis. VitD and its metabolites are highly hydrophobic and circulate mostly bound to the vitamin D binding protein (DBP) and with lower affinity to albumin, while less than 1% are in a free form. The aim of this study was to investigate whether the circulating levels of either of the two vitD plasma carriers and/or their relationship are altered in MS. We measured DBP and albumin plasma levels in 28 MS patients and 24 healthy controls. MS patients were found to have higher DBP levels than healthy subjects. Concomitant interferon beta therapy did not influence DBP concentration, and the difference with the control group was significant in both females and males. No significant correlation between DBP and albumin levels was observed either in healthy controls or in patients. These observations suggest the involvement of DBP in the patho-physiology of MS.
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spelling pubmed-43038182015-02-02 Increased Circulating Levels of Vitamin D Binding Protein in MS Patients Rinaldi, Arturo Ottavio Sanseverino, Isabella Purificato, Cristina Cortese, Antonio Mechelli, Rosella Francisci, Silvia Salvetti, Marco Millefiorini, Enrico Gessani, Sandra Gauzzi, Maria Cristina Toxins (Basel) Communication Vitamin D (vitD) low status is currently considered a main environmental factor in multiple sclerosis (MS) etiology and pathogenesis. VitD and its metabolites are highly hydrophobic and circulate mostly bound to the vitamin D binding protein (DBP) and with lower affinity to albumin, while less than 1% are in a free form. The aim of this study was to investigate whether the circulating levels of either of the two vitD plasma carriers and/or their relationship are altered in MS. We measured DBP and albumin plasma levels in 28 MS patients and 24 healthy controls. MS patients were found to have higher DBP levels than healthy subjects. Concomitant interferon beta therapy did not influence DBP concentration, and the difference with the control group was significant in both females and males. No significant correlation between DBP and albumin levels was observed either in healthy controls or in patients. These observations suggest the involvement of DBP in the patho-physiology of MS. MDPI 2015-01-13 /pmc/articles/PMC4303818/ /pubmed/25590278 http://dx.doi.org/10.3390/toxins7010129 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Rinaldi, Arturo Ottavio
Sanseverino, Isabella
Purificato, Cristina
Cortese, Antonio
Mechelli, Rosella
Francisci, Silvia
Salvetti, Marco
Millefiorini, Enrico
Gessani, Sandra
Gauzzi, Maria Cristina
Increased Circulating Levels of Vitamin D Binding Protein in MS Patients
title Increased Circulating Levels of Vitamin D Binding Protein in MS Patients
title_full Increased Circulating Levels of Vitamin D Binding Protein in MS Patients
title_fullStr Increased Circulating Levels of Vitamin D Binding Protein in MS Patients
title_full_unstemmed Increased Circulating Levels of Vitamin D Binding Protein in MS Patients
title_short Increased Circulating Levels of Vitamin D Binding Protein in MS Patients
title_sort increased circulating levels of vitamin d binding protein in ms patients
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303818/
https://www.ncbi.nlm.nih.gov/pubmed/25590278
http://dx.doi.org/10.3390/toxins7010129
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