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Nutritionally-Induced Catch-Up Growth

Malnutrition is considered a leading cause of growth attenuation in children. When food is replenished, spontaneous catch-up (CU) growth usually occurs, bringing the child back to its original growth trajectory. However, in some cases, the CU growth is not complete, leading to a permanent growth def...

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Detalles Bibliográficos
Autores principales: Gat-Yablonski, Galia, Phillip, Moshe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303852/
https://www.ncbi.nlm.nih.gov/pubmed/25594438
http://dx.doi.org/10.3390/nu7010517
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author Gat-Yablonski, Galia
Phillip, Moshe
author_facet Gat-Yablonski, Galia
Phillip, Moshe
author_sort Gat-Yablonski, Galia
collection PubMed
description Malnutrition is considered a leading cause of growth attenuation in children. When food is replenished, spontaneous catch-up (CU) growth usually occurs, bringing the child back to its original growth trajectory. However, in some cases, the CU growth is not complete, leading to a permanent growth deficit. This review summarizes our current knowledge regarding the mechanism regulating nutrition and growth, including systemic factors, such as insulin, growth hormone, insulin- like growth factor-1, vitamin D, fibroblast growth factor-21, etc., and local mechanisms, including autophagy, as well as regulators of transcription, protein synthesis, miRNAs and epigenetics. Studying the molecular mechanisms regulating CU growth may lead to the establishment of better nutritional and therapeutic regimens for more effective CU growth in children with malnutrition and growth abnormalities. It will be fascinating to follow this research in the coming years and to translate the knowledge gained to clinical benefit.
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spelling pubmed-43038522015-02-02 Nutritionally-Induced Catch-Up Growth Gat-Yablonski, Galia Phillip, Moshe Nutrients Review Malnutrition is considered a leading cause of growth attenuation in children. When food is replenished, spontaneous catch-up (CU) growth usually occurs, bringing the child back to its original growth trajectory. However, in some cases, the CU growth is not complete, leading to a permanent growth deficit. This review summarizes our current knowledge regarding the mechanism regulating nutrition and growth, including systemic factors, such as insulin, growth hormone, insulin- like growth factor-1, vitamin D, fibroblast growth factor-21, etc., and local mechanisms, including autophagy, as well as regulators of transcription, protein synthesis, miRNAs and epigenetics. Studying the molecular mechanisms regulating CU growth may lead to the establishment of better nutritional and therapeutic regimens for more effective CU growth in children with malnutrition and growth abnormalities. It will be fascinating to follow this research in the coming years and to translate the knowledge gained to clinical benefit. MDPI 2015-01-14 /pmc/articles/PMC4303852/ /pubmed/25594438 http://dx.doi.org/10.3390/nu7010517 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gat-Yablonski, Galia
Phillip, Moshe
Nutritionally-Induced Catch-Up Growth
title Nutritionally-Induced Catch-Up Growth
title_full Nutritionally-Induced Catch-Up Growth
title_fullStr Nutritionally-Induced Catch-Up Growth
title_full_unstemmed Nutritionally-Induced Catch-Up Growth
title_short Nutritionally-Induced Catch-Up Growth
title_sort nutritionally-induced catch-up growth
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303852/
https://www.ncbi.nlm.nih.gov/pubmed/25594438
http://dx.doi.org/10.3390/nu7010517
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