Cargando…

The Effect on Selenium Concentrations of a Randomized Intervention with Fish and Mussels in a Population with Relatively Low Habitual Dietary Selenium Intake

Selenium status of the Danish population is below that assumed optimal for the suggested protective effects against chronic diseases, including certain cancers. Fish and shellfish are important dietary sources of selenium in Denmark. We investigated the effect of increased fish and mussel intake on...

Descripción completa

Detalles Bibliográficos
Autores principales: Outzen, Malene, Tjønneland, Anne, Larsen, Erik H., Andersen, Klaus K., Christensen, Jane, Overvad, Kim, Olsen, Anja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303857/
https://www.ncbi.nlm.nih.gov/pubmed/25599275
http://dx.doi.org/10.3390/nu7010608
_version_ 1782353986899148800
author Outzen, Malene
Tjønneland, Anne
Larsen, Erik H.
Andersen, Klaus K.
Christensen, Jane
Overvad, Kim
Olsen, Anja
author_facet Outzen, Malene
Tjønneland, Anne
Larsen, Erik H.
Andersen, Klaus K.
Christensen, Jane
Overvad, Kim
Olsen, Anja
author_sort Outzen, Malene
collection PubMed
description Selenium status of the Danish population is below that assumed optimal for the suggested protective effects against chronic diseases, including certain cancers. Fish and shellfish are important dietary sources of selenium in Denmark. We investigated the effect of increased fish and mussel intake on selenium blood concentrations in a population with relatively low habitual dietary selenium intake. We randomly assigned 102 healthy men and women (all non-smokers) aged 48–76 years to an intervention group (n = 51) or a control group (n = 51). Intervention participants received 1000 g fish and mussels/week for 26 weeks (~50 μg selenium/day). Controls received no intervention. Non-fasting blood samples were taken and whole blood selenium was determined using inductively coupled plasma-mass spectrometry (ICP-MS), and plasma selenoprotein P (SelP) was determined by high performance liquid chromatography coupled to ICP-MS. All available observations were included in linear multiple regression analysis to evaluate the effect of the intervention. The difference in mean change for intervention compared with control persons was 14.9 ng/mL (95% CI: 10.2, 19.7) for whole blood selenium, and 7.0 ng/mL (95% CI: 3.1, 10.9) for plasma SelP (Weeks 0–26). Selenium concentrations were significantly increased after 26 weeks of intervention, albeit to a lower degree than expected.
format Online
Article
Text
id pubmed-4303857
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-43038572015-02-02 The Effect on Selenium Concentrations of a Randomized Intervention with Fish and Mussels in a Population with Relatively Low Habitual Dietary Selenium Intake Outzen, Malene Tjønneland, Anne Larsen, Erik H. Andersen, Klaus K. Christensen, Jane Overvad, Kim Olsen, Anja Nutrients Article Selenium status of the Danish population is below that assumed optimal for the suggested protective effects against chronic diseases, including certain cancers. Fish and shellfish are important dietary sources of selenium in Denmark. We investigated the effect of increased fish and mussel intake on selenium blood concentrations in a population with relatively low habitual dietary selenium intake. We randomly assigned 102 healthy men and women (all non-smokers) aged 48–76 years to an intervention group (n = 51) or a control group (n = 51). Intervention participants received 1000 g fish and mussels/week for 26 weeks (~50 μg selenium/day). Controls received no intervention. Non-fasting blood samples were taken and whole blood selenium was determined using inductively coupled plasma-mass spectrometry (ICP-MS), and plasma selenoprotein P (SelP) was determined by high performance liquid chromatography coupled to ICP-MS. All available observations were included in linear multiple regression analysis to evaluate the effect of the intervention. The difference in mean change for intervention compared with control persons was 14.9 ng/mL (95% CI: 10.2, 19.7) for whole blood selenium, and 7.0 ng/mL (95% CI: 3.1, 10.9) for plasma SelP (Weeks 0–26). Selenium concentrations were significantly increased after 26 weeks of intervention, albeit to a lower degree than expected. MDPI 2015-01-15 /pmc/articles/PMC4303857/ /pubmed/25599275 http://dx.doi.org/10.3390/nu7010608 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Outzen, Malene
Tjønneland, Anne
Larsen, Erik H.
Andersen, Klaus K.
Christensen, Jane
Overvad, Kim
Olsen, Anja
The Effect on Selenium Concentrations of a Randomized Intervention with Fish and Mussels in a Population with Relatively Low Habitual Dietary Selenium Intake
title The Effect on Selenium Concentrations of a Randomized Intervention with Fish and Mussels in a Population with Relatively Low Habitual Dietary Selenium Intake
title_full The Effect on Selenium Concentrations of a Randomized Intervention with Fish and Mussels in a Population with Relatively Low Habitual Dietary Selenium Intake
title_fullStr The Effect on Selenium Concentrations of a Randomized Intervention with Fish and Mussels in a Population with Relatively Low Habitual Dietary Selenium Intake
title_full_unstemmed The Effect on Selenium Concentrations of a Randomized Intervention with Fish and Mussels in a Population with Relatively Low Habitual Dietary Selenium Intake
title_short The Effect on Selenium Concentrations of a Randomized Intervention with Fish and Mussels in a Population with Relatively Low Habitual Dietary Selenium Intake
title_sort effect on selenium concentrations of a randomized intervention with fish and mussels in a population with relatively low habitual dietary selenium intake
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303857/
https://www.ncbi.nlm.nih.gov/pubmed/25599275
http://dx.doi.org/10.3390/nu7010608
work_keys_str_mv AT outzenmalene theeffectonseleniumconcentrationsofarandomizedinterventionwithfishandmusselsinapopulationwithrelativelylowhabitualdietaryseleniumintake
AT tjønnelandanne theeffectonseleniumconcentrationsofarandomizedinterventionwithfishandmusselsinapopulationwithrelativelylowhabitualdietaryseleniumintake
AT larsenerikh theeffectonseleniumconcentrationsofarandomizedinterventionwithfishandmusselsinapopulationwithrelativelylowhabitualdietaryseleniumintake
AT andersenklausk theeffectonseleniumconcentrationsofarandomizedinterventionwithfishandmusselsinapopulationwithrelativelylowhabitualdietaryseleniumintake
AT christensenjane theeffectonseleniumconcentrationsofarandomizedinterventionwithfishandmusselsinapopulationwithrelativelylowhabitualdietaryseleniumintake
AT overvadkim theeffectonseleniumconcentrationsofarandomizedinterventionwithfishandmusselsinapopulationwithrelativelylowhabitualdietaryseleniumintake
AT olsenanja theeffectonseleniumconcentrationsofarandomizedinterventionwithfishandmusselsinapopulationwithrelativelylowhabitualdietaryseleniumintake
AT outzenmalene effectonseleniumconcentrationsofarandomizedinterventionwithfishandmusselsinapopulationwithrelativelylowhabitualdietaryseleniumintake
AT tjønnelandanne effectonseleniumconcentrationsofarandomizedinterventionwithfishandmusselsinapopulationwithrelativelylowhabitualdietaryseleniumintake
AT larsenerikh effectonseleniumconcentrationsofarandomizedinterventionwithfishandmusselsinapopulationwithrelativelylowhabitualdietaryseleniumintake
AT andersenklausk effectonseleniumconcentrationsofarandomizedinterventionwithfishandmusselsinapopulationwithrelativelylowhabitualdietaryseleniumintake
AT christensenjane effectonseleniumconcentrationsofarandomizedinterventionwithfishandmusselsinapopulationwithrelativelylowhabitualdietaryseleniumintake
AT overvadkim effectonseleniumconcentrationsofarandomizedinterventionwithfishandmusselsinapopulationwithrelativelylowhabitualdietaryseleniumintake
AT olsenanja effectonseleniumconcentrationsofarandomizedinterventionwithfishandmusselsinapopulationwithrelativelylowhabitualdietaryseleniumintake