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Noninvasive In Vivo Imaging of Diabetes-Induced Renal Oxidative Stress and Response to Therapy Using Hyperpolarized (13)C Dehydroascorbate Magnetic Resonance

Oxidative stress has been proposed to be a unifying cause for diabetic nephropathy and a target for novel therapies. Here we apply a new endogenous reduction-oxidation (redox) sensor, hyperpolarized (HP) (13)C dehydroascorbate (DHA), in conjunction with MRI to noninvasively interrogate the renal red...

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Detalles Bibliográficos
Autores principales:	Keshari, Kayvan R., Wilson, David M., Sai, Victor, Bok, Robert, Jen, Kuang-Yu, Larson, Peder, Van Criekinge, Mark, Kurhanewicz, John, Wang, Zhen J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2015
Materias:	Technological Advances
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303960/ https://www.ncbi.nlm.nih.gov/pubmed/25187363 http://dx.doi.org/10.2337/db13-1829

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