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PD-L1–Driven Tolerance Protects Neurogenin3-Induced Islet Neogenesis to Reverse Established Type 1 Diabetes in NOD Mice

A breakdown in self-tolerance underlies autoimmune destruction of β-cells and type 1 diabetes. A cure by restoring β-cell mass is limited by the availability of transplantable β-cells and the need for chronic immunosuppression. Evidence indicates that inhibiting costimulation through the PD-1/PD-L1...

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Detalles Bibliográficos
Autores principales:	Li, Rongying, Lee, Jeongkyung, Kim, Mi-sun, Liu, Victoria, Moulik, Mousumi, Li, Haiyan, Yi, Qing, Xie, Aini, Chen, Wenhao, Yang, Lina, Li, Yimin, Tsai, Tsung Huang, Oka, Kazuhiro, Chan, Lawrence, Yechoor, Vijay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2015
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303975/ https://www.ncbi.nlm.nih.gov/pubmed/25332429 http://dx.doi.org/10.2337/db13-1737

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