The secreted protein S100A7 (psoriasin) is induced by telomere dysfunction in human keratinocytes independently of a DNA damage response and cell cycle regulators

BACKGROUND: Replicative senescence is preceded by loss of repeat sequences of DNA from the telomeres that eventually leads to telomere dysfunction, the accumulation of irreparable DNA double strand breaks and a DNA damage response (DDR). However, we have previously reported that whilst telomere dysf...

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Detalles Bibliográficos
Autores principales: de Castro, Alice, Minty, Fay, Hattinger, Eva, Wolf, Ronald, Parkinson, Eric Kenneth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304136/
https://www.ncbi.nlm.nih.gov/pubmed/25621169
http://dx.doi.org/10.1186/2046-2395-3-8

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