Cargando…
U0126 Protects Cells against Oxidative Stress Independent of Its Function as a MEK Inhibitor
[Image: see text] U0126 is a potent and selective inhibitor of MEK1 and MEK2 kinases. It has been widely used as an inhibitor for the Ras/Raf/MEK/ERK signaling pathway with over 5000 references on the NCBI PubMed database. In particular, U0126 has been used in a number of studies to show that inhibi...
Autores principales: | Ong, Qunxiang, Guo, Shunling, Zhang, Kai, Cui, Bianxiao |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2014
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304487/ https://www.ncbi.nlm.nih.gov/pubmed/25544156 http://dx.doi.org/10.1021/cn500288n |
Ejemplares similares
-
The Timing of Raf/ERK and AKT Activation in Protecting PC12 Cells against Oxidative Stress
por: Ong, Qunxiang, et al.
Publicado: (2016) -
MEK Inhibitor U0126 Reverses Protection of Axons from Wallerian Degeneration Independently of MEK–ERK Signaling
por: Evans, Catherine, et al.
Publicado: (2013) -
Potent block of potassium channels by MEK inhibitor U0126 in primary cultures and brain slices
por: Wang, Jin-Zhao, et al.
Publicado: (2018) -
The small molecule Mek1/2 inhibitor U0126 disrupts the chordamesoderm to notochord transition in zebrafish
por: Hawkins, Thomas A, et al.
Publicado: (2008) -
The MEK inhibitor U0126 ameliorates diabetic cardiomyopathy by restricting XBP1's phosphorylation dependent SUMOylation
por: Wang, Tao, et al.
Publicado: (2021)