Plumbagin induces cell cycle arrest and autophagy and suppresses epithelial to mesenchymal transition involving PI3K/Akt/mTOR-mediated pathway in human pancreatic cancer cells

Plumbagin (PLB), an active naphthoquinone compound, has shown potent anticancer effects in preclinical studies; however, the effect and underlying mechanism of PLB for the treatment of pancreatic cancer is unclear. This study aimed to examine the pancreatic cancer cell killing effect of PLB and inve...

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Detalles Bibliográficos
Autores principales: Wang, Feng, Wang, Qi, Zhou, Zhi-Wei, Yu, Song-Ning, Pan, Shu-Ting, He, Zhi-Xu, Zhang, Xueji, Wang, Dong, Yang, Yin-Xue, Yang, Tianxing, Sun, Tao, Li, Min, Qiu, Jia-Xuan, Zhou, Shu-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304578/
https://www.ncbi.nlm.nih.gov/pubmed/25632222
http://dx.doi.org/10.2147/DDDT.S73689

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