Combination therapy of ursodeoxycholic acid and budesonide for PBC–AIH overlap syndrome: a meta-analysis

In this study, a meta-analysis of randomized controlled trials comparing ursodeoxycholic acid (UDCA) monotherapy with combination therapies utilizing UDCA and budesonide was performed. We found that combination therapy with UDCA and budesonide was more effective than UDCA monotherapy for primary bil...

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Autores principales: Zhang, Huawei, Yang, Jing, Zhu, Rong, Zheng, Yuanyuan, Zhou, Yuqing, Dai, Weiqi, Wang, Fan, Chen, Kan, Li, Jingjing, Wang, Chengfen, Li, Sainan, Liu, Tong, Abudumijiti, Huerxidan, Zhou, Zheng, Wang, Jianrong, Lu, Wenxia, Wang, Junshan, Xia, Yujing, Zhou, Yingqun, Lu, Jie, Guo, Chuanyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304592/
https://www.ncbi.nlm.nih.gov/pubmed/25632224
http://dx.doi.org/10.2147/DDDT.S74515
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author Zhang, Huawei
Yang, Jing
Zhu, Rong
Zheng, Yuanyuan
Zhou, Yuqing
Dai, Weiqi
Wang, Fan
Chen, Kan
Li, Jingjing
Wang, Chengfen
Li, Sainan
Liu, Tong
Abudumijiti, Huerxidan
Zhou, Zheng
Wang, Jianrong
Lu, Wenxia
Wang, Junshan
Xia, Yujing
Zhou, Yingqun
Lu, Jie
Guo, Chuanyong
author_facet Zhang, Huawei
Yang, Jing
Zhu, Rong
Zheng, Yuanyuan
Zhou, Yuqing
Dai, Weiqi
Wang, Fan
Chen, Kan
Li, Jingjing
Wang, Chengfen
Li, Sainan
Liu, Tong
Abudumijiti, Huerxidan
Zhou, Zheng
Wang, Jianrong
Lu, Wenxia
Wang, Junshan
Xia, Yujing
Zhou, Yingqun
Lu, Jie
Guo, Chuanyong
author_sort Zhang, Huawei
collection PubMed
description In this study, a meta-analysis of randomized controlled trials comparing ursodeoxycholic acid (UDCA) monotherapy with combination therapies utilizing UDCA and budesonide was performed. We found that combination therapy with UDCA and budesonide was more effective than UDCA monotherapy for primary biliary cirrhosis–autoimmune hepatitis overlap syndrome. Moreover, compared to prednisone, budesonide has fewer side effects.
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spelling pubmed-43045922015-01-28 Combination therapy of ursodeoxycholic acid and budesonide for PBC–AIH overlap syndrome: a meta-analysis Zhang, Huawei Yang, Jing Zhu, Rong Zheng, Yuanyuan Zhou, Yuqing Dai, Weiqi Wang, Fan Chen, Kan Li, Jingjing Wang, Chengfen Li, Sainan Liu, Tong Abudumijiti, Huerxidan Zhou, Zheng Wang, Jianrong Lu, Wenxia Wang, Junshan Xia, Yujing Zhou, Yingqun Lu, Jie Guo, Chuanyong Drug Des Devel Ther Review In this study, a meta-analysis of randomized controlled trials comparing ursodeoxycholic acid (UDCA) monotherapy with combination therapies utilizing UDCA and budesonide was performed. We found that combination therapy with UDCA and budesonide was more effective than UDCA monotherapy for primary biliary cirrhosis–autoimmune hepatitis overlap syndrome. Moreover, compared to prednisone, budesonide has fewer side effects. Dove Medical Press 2015-01-17 /pmc/articles/PMC4304592/ /pubmed/25632224 http://dx.doi.org/10.2147/DDDT.S74515 Text en © 2015 Zhang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Zhang, Huawei
Yang, Jing
Zhu, Rong
Zheng, Yuanyuan
Zhou, Yuqing
Dai, Weiqi
Wang, Fan
Chen, Kan
Li, Jingjing
Wang, Chengfen
Li, Sainan
Liu, Tong
Abudumijiti, Huerxidan
Zhou, Zheng
Wang, Jianrong
Lu, Wenxia
Wang, Junshan
Xia, Yujing
Zhou, Yingqun
Lu, Jie
Guo, Chuanyong
Combination therapy of ursodeoxycholic acid and budesonide for PBC–AIH overlap syndrome: a meta-analysis
title Combination therapy of ursodeoxycholic acid and budesonide for PBC–AIH overlap syndrome: a meta-analysis
title_full Combination therapy of ursodeoxycholic acid and budesonide for PBC–AIH overlap syndrome: a meta-analysis
title_fullStr Combination therapy of ursodeoxycholic acid and budesonide for PBC–AIH overlap syndrome: a meta-analysis
title_full_unstemmed Combination therapy of ursodeoxycholic acid and budesonide for PBC–AIH overlap syndrome: a meta-analysis
title_short Combination therapy of ursodeoxycholic acid and budesonide for PBC–AIH overlap syndrome: a meta-analysis
title_sort combination therapy of ursodeoxycholic acid and budesonide for pbc–aih overlap syndrome: a meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304592/
https://www.ncbi.nlm.nih.gov/pubmed/25632224
http://dx.doi.org/10.2147/DDDT.S74515
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