Identification and characterization of novel factors that act in the nonsense-mediated mRNA decay pathway in nematodes, flies and mammals

Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that degrades mRNAs harboring premature termination codons (PTCs). We have conducted a genome-wide RNAi screen in Caenorhabditis elegans that resulted in the identification of five novel NMD genes that are conserved throughout evolution....

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Detalles Bibliográficos
Autores principales: Casadio, Angela, Longman, Dasa, Hug, Nele, Delavaine, Laurent, Vallejos Baier, Raúl, Alonso, Claudio R, Cáceres, Javier F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Scientific Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304730/
https://www.ncbi.nlm.nih.gov/pubmed/25452588
http://dx.doi.org/10.15252/embr.201439183

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