Beneficial Effects of Canagliflozin in Combination with Pioglitazone on Insulin Sensitivity in Rodent Models of Obese Type 2 Diabetes

BACKGROUND: Despite its insulin sensitizing effects, pioglitazone may induce weight gain leading to an increased risk of development of insulin resistance. A novel sodium glucose co-transporter 2 (SGLT2) inhibitor, canagliflozin, provides not only glycemic control but also body weight reduction thro...

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Detalles Bibliográficos
Autores principales: Watanabe, Yoshinori, Nakayama, Keiko, Taniuchi, Nobuhiko, Horai, Yasushi, Kuriyama, Chiaki, Ueta, Kiichiro, Arakawa, Kenji, Senbonmatsu, Takaaki, Shiotani, Masaharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304810/
https://www.ncbi.nlm.nih.gov/pubmed/25615826
http://dx.doi.org/10.1371/journal.pone.0116851

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