Six Amino Acid Residues in a 1200 Å2 Interface Mediate Binding of Factor VIII to an IgG4κ Inhibitory Antibody

The development of neutralizing anti-factor VIII (FVIII) antibodies complicates the treatment of many hemophilia A patients. The C-terminal C2 domain is a particularly antigenic FVIII region. A crystal structure of recombinant FVIII-C2 bound to an Fab fragment of the patient-derived monoclonal antib...

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Detalles Bibliográficos
Autores principales: Lin, Jasper C., Ettinger, Ruth A., Schuman, Jason T., Zhang, Ai-Hong, Wamiq-Adhami, Muhammad, Nguyen, Phuong-Cac T., Nakaya-Fletcher, Shelley M., Puranik, Komal, Thompson, Arthur R., Pratt, Kathleen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304825/
https://www.ncbi.nlm.nih.gov/pubmed/25615825
http://dx.doi.org/10.1371/journal.pone.0116577

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