The physiologic and therapeutic role of heparin in implantation and placentation

Implantation, trophoblast development and placentation are crucial processes in the establishment and development of normal pregnancy. Abnormalities of these processes can lead to pregnancy complications known as the great obstetrical syndromes: preeclampsia, intrauterine growth restriction, fetal d...

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Autores principales: Quaranta, Michela, Erez, Offer, Mastrolia, Salvatore Andrea, Koifman, Arie, Leron, Elad, Eshkoli, Tamar, Mazor, Moshe, Holcberg, Gershon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2015
Materias:
Gynecology and Obstetrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304855/
https://www.ncbi.nlm.nih.gov/pubmed/25653897
http://dx.doi.org/10.7717/peerj.691
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author Quaranta, Michela
Erez, Offer
Mastrolia, Salvatore Andrea
Koifman, Arie
Leron, Elad
Eshkoli, Tamar
Mazor, Moshe
Holcberg, Gershon
author_facet Quaranta, Michela
Erez, Offer
Mastrolia, Salvatore Andrea
Koifman, Arie
Leron, Elad
Eshkoli, Tamar
Mazor, Moshe
Holcberg, Gershon
author_sort Quaranta, Michela
collection PubMed
description Implantation, trophoblast development and placentation are crucial processes in the establishment and development of normal pregnancy. Abnormalities of these processes can lead to pregnancy complications known as the great obstetrical syndromes: preeclampsia, intrauterine growth restriction, fetal demise, premature prelabor rupture of membranes, preterm labor, and recurrent pregnancy loss. There is mounting evidence regarding the physiological and therapeutic role of heparins in the establishment of normal gestation and as a modality for treatment and prevention of pregnancy complications. In this review, we will summarize the properties and the physiological contributions of heparins to the success of implantation, placentation and normal pregnancy.
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spelling pubmed-43048552015-02-04 The physiologic and therapeutic role of heparin in implantation and placentation Quaranta, Michela Erez, Offer Mastrolia, Salvatore Andrea Koifman, Arie Leron, Elad Eshkoli, Tamar Mazor, Moshe Holcberg, Gershon PeerJ Gynecology and Obstetrics Implantation, trophoblast development and placentation are crucial processes in the establishment and development of normal pregnancy. Abnormalities of these processes can lead to pregnancy complications known as the great obstetrical syndromes: preeclampsia, intrauterine growth restriction, fetal demise, premature prelabor rupture of membranes, preterm labor, and recurrent pregnancy loss. There is mounting evidence regarding the physiological and therapeutic role of heparins in the establishment of normal gestation and as a modality for treatment and prevention of pregnancy complications. In this review, we will summarize the properties and the physiological contributions of heparins to the success of implantation, placentation and normal pregnancy. PeerJ Inc. 2015-01-06 /pmc/articles/PMC4304855/ /pubmed/25653897 http://dx.doi.org/10.7717/peerj.691 Text en © 2015 Quaranta et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Gynecology and Obstetrics
Quaranta, Michela
Erez, Offer
Mastrolia, Salvatore Andrea
Koifman, Arie
Leron, Elad
Eshkoli, Tamar
Mazor, Moshe
Holcberg, Gershon
The physiologic and therapeutic role of heparin in implantation and placentation
title The physiologic and therapeutic role of heparin in implantation and placentation
title_full The physiologic and therapeutic role of heparin in implantation and placentation
title_fullStr The physiologic and therapeutic role of heparin in implantation and placentation
title_full_unstemmed The physiologic and therapeutic role of heparin in implantation and placentation
title_short The physiologic and therapeutic role of heparin in implantation and placentation
title_sort physiologic and therapeutic role of heparin in implantation and placentation
topic Gynecology and Obstetrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304855/
https://www.ncbi.nlm.nih.gov/pubmed/25653897
http://dx.doi.org/10.7717/peerj.691
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