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Two Novel α7 Nicotinic Acetylcholine Receptor Ligands: In Vitro Properties and Their Efficacy in Collagen-Induced Arthritis in Mice

INTRODUCTION: The cholinergic anti-inflammatory pathway can downregulate inflammation via the release of acetylcholine (ACh) by the vagus nerve. This neurotransmitter binds to the α7 subunit of nicotinic acetylcholine receptors (α7nAChR), expressed on macrophages and other immune cells. We tested th...

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Detalles Bibliográficos
Autores principales:	van Maanen, Marjolein A., Papke, Roger L., Koopman, Frieda A., Koepke, Jessica, Bevaart, Lisette, Clark, Roger, Lamppu, Diana, Elbaum, Daniel, LaRosa, Gregory J., Tak, Paul P., Vervoordeldonk, Margriet J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305287/ https://www.ncbi.nlm.nih.gov/pubmed/25617631 http://dx.doi.org/10.1371/journal.pone.0116227

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