JAK2 Exon 14 Skipping in Patients with Primary Myelofibrosis: A Minor Splice Variant Modulated by the JAK2-V617F Allele Burden

BACKGROUND: Primary myelofibrosis (PMF) is an acquired clonal disease of the hematopoietic stem cell compartment, characterized by bone marrow fibrosis, anemia, splenomegaly and extramedullary hematopoiesis. About 60% of patients with PMF harbor a somatic mutation of the JAK2 gene (JAK2-V617F) in th...

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Detalles Bibliográficos
Autores principales: Catarsi, Paolo, Rosti, Vittorio, Morreale, Giacomo, Poletto, Valentina, Villani, Laura, Bertorelli, Roberto, Pedrazzini, Matteo, Zorzetto, Michele, Barosi, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305294/
https://www.ncbi.nlm.nih.gov/pubmed/25617626
http://dx.doi.org/10.1371/journal.pone.0116636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305294/
https://www.ncbi.nlm.nih.gov/pubmed/25617626
http://dx.doi.org/10.1371/journal.pone.0116636

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