Cargando…
Magnetic field effects as a result of the radical pair mechanism are unlikely in redox enzymes
Environmental exposure to electromagnetic fields is potentially carcinogenic. The radical pair mechanism is considered the most feasible mechanism of interaction between weak magnetic fields encountered in our environment and biochemical systems. Radicals are abundant in biology, both as free radica...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305418/ https://www.ncbi.nlm.nih.gov/pubmed/25505136 http://dx.doi.org/10.1098/rsif.2014.1155 |
_version_ | 1782354230008348672 |
---|---|
author | Messiha, Hanan L. Wongnate, Thanyaporn Chaiyen, Pimchai Jones, Alex R. Scrutton, Nigel S. |
author_facet | Messiha, Hanan L. Wongnate, Thanyaporn Chaiyen, Pimchai Jones, Alex R. Scrutton, Nigel S. |
author_sort | Messiha, Hanan L. |
collection | PubMed |
description | Environmental exposure to electromagnetic fields is potentially carcinogenic. The radical pair mechanism is considered the most feasible mechanism of interaction between weak magnetic fields encountered in our environment and biochemical systems. Radicals are abundant in biology, both as free radicals and reaction intermediates in enzyme mechanisms. The catalytic cycles of some flavin-dependent enzymes are either known or potentially involve radical pairs. Here, we have investigated the magnetic field sensitivity of a number of flavoenzymes with important cellular roles. We also investigated the magnetic field sensitivity of a model system involving stepwise reduction of a flavin analogue by a nicotinamide analogue—a reaction known to proceed via a radical pair. Under the experimental conditions used, magnetic field sensitivity was not observed in the reaction kinetics from stopped-flow measurements in any of the systems studied. Although widely implicated in radical pair chemistry, we conclude that thermally driven, flavoenzyme-catalysed reactions are unlikely to be influenced by exposure to external magnetic fields. |
format | Online Article Text |
id | pubmed-4305418 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-43054182015-02-06 Magnetic field effects as a result of the radical pair mechanism are unlikely in redox enzymes Messiha, Hanan L. Wongnate, Thanyaporn Chaiyen, Pimchai Jones, Alex R. Scrutton, Nigel S. J R Soc Interface Research Articles Environmental exposure to electromagnetic fields is potentially carcinogenic. The radical pair mechanism is considered the most feasible mechanism of interaction between weak magnetic fields encountered in our environment and biochemical systems. Radicals are abundant in biology, both as free radicals and reaction intermediates in enzyme mechanisms. The catalytic cycles of some flavin-dependent enzymes are either known or potentially involve radical pairs. Here, we have investigated the magnetic field sensitivity of a number of flavoenzymes with important cellular roles. We also investigated the magnetic field sensitivity of a model system involving stepwise reduction of a flavin analogue by a nicotinamide analogue—a reaction known to proceed via a radical pair. Under the experimental conditions used, magnetic field sensitivity was not observed in the reaction kinetics from stopped-flow measurements in any of the systems studied. Although widely implicated in radical pair chemistry, we conclude that thermally driven, flavoenzyme-catalysed reactions are unlikely to be influenced by exposure to external magnetic fields. The Royal Society 2015-02-06 /pmc/articles/PMC4305418/ /pubmed/25505136 http://dx.doi.org/10.1098/rsif.2014.1155 Text en http://creativecommons.org/licenses/by/4.0/ © 2014 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Research Articles Messiha, Hanan L. Wongnate, Thanyaporn Chaiyen, Pimchai Jones, Alex R. Scrutton, Nigel S. Magnetic field effects as a result of the radical pair mechanism are unlikely in redox enzymes |
title | Magnetic field effects as a result of the radical pair mechanism are unlikely in redox enzymes |
title_full | Magnetic field effects as a result of the radical pair mechanism are unlikely in redox enzymes |
title_fullStr | Magnetic field effects as a result of the radical pair mechanism are unlikely in redox enzymes |
title_full_unstemmed | Magnetic field effects as a result of the radical pair mechanism are unlikely in redox enzymes |
title_short | Magnetic field effects as a result of the radical pair mechanism are unlikely in redox enzymes |
title_sort | magnetic field effects as a result of the radical pair mechanism are unlikely in redox enzymes |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305418/ https://www.ncbi.nlm.nih.gov/pubmed/25505136 http://dx.doi.org/10.1098/rsif.2014.1155 |
work_keys_str_mv | AT messihahananl magneticfieldeffectsasaresultoftheradicalpairmechanismareunlikelyinredoxenzymes AT wongnatethanyaporn magneticfieldeffectsasaresultoftheradicalpairmechanismareunlikelyinredoxenzymes AT chaiyenpimchai magneticfieldeffectsasaresultoftheradicalpairmechanismareunlikelyinredoxenzymes AT jonesalexr magneticfieldeffectsasaresultoftheradicalpairmechanismareunlikelyinredoxenzymes AT scruttonnigels magneticfieldeffectsasaresultoftheradicalpairmechanismareunlikelyinredoxenzymes |