Protein phosphatase 2C-alpha knockdown reduces angiotensin II-mediated skeletal muscle wasting via restoration of mitochondrial recycling and function

BACKGROUND: Circulating angiotensin II (AngII) is elevated in congestive heart failure (CHF), and leads to skeletal muscle wasting, which is strongly associated with poor patient outcomes. We previously found that AngII upregulates protein phosphatase 2C-alpha (PP2Cα) and dephosphorylates AMP-activa...

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Detalles Bibliográficos
Autores principales: Tabony, Alexander Michael, Yoshida, Tadashi, Sukhanov, Sergiy, Delafontaine, Patrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306116/
https://www.ncbi.nlm.nih.gov/pubmed/25625009
http://dx.doi.org/10.1186/2044-5040-4-20

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