Uncertainty of Prebiotic Scenarios: The Case of the Non-Enzymatic Reverse Tricarboxylic Acid Cycle

We consider the hypothesis of the primordial nature of the non-enzymatic reverse tricarboxylic acid (rTCA) cycle and describe a modeling approach to quantify the uncertainty of this hypothesis due to the combinatorial aspect of the constituent chemical transformations. Our results suggest that a) rT...

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Autores principales: Zubarev, Dmitry Yu, Rappoport, Dmitrij, Aspuru-Guzik, Alán
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306138/
https://www.ncbi.nlm.nih.gov/pubmed/25620471
http://dx.doi.org/10.1038/srep08009
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author Zubarev, Dmitry Yu
Rappoport, Dmitrij
Aspuru-Guzik, Alán
author_facet Zubarev, Dmitry Yu
Rappoport, Dmitrij
Aspuru-Guzik, Alán
author_sort Zubarev, Dmitry Yu
collection PubMed
description We consider the hypothesis of the primordial nature of the non-enzymatic reverse tricarboxylic acid (rTCA) cycle and describe a modeling approach to quantify the uncertainty of this hypothesis due to the combinatorial aspect of the constituent chemical transformations. Our results suggest that a) rTCA cycle belongs to a degenerate optimum of auto-catalytic cycles, and b) the set of targets for investigations of the origin of the common metabolic core should be significantly extended.
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spelling pubmed-43061382015-02-05 Uncertainty of Prebiotic Scenarios: The Case of the Non-Enzymatic Reverse Tricarboxylic Acid Cycle Zubarev, Dmitry Yu Rappoport, Dmitrij Aspuru-Guzik, Alán Sci Rep Article We consider the hypothesis of the primordial nature of the non-enzymatic reverse tricarboxylic acid (rTCA) cycle and describe a modeling approach to quantify the uncertainty of this hypothesis due to the combinatorial aspect of the constituent chemical transformations. Our results suggest that a) rTCA cycle belongs to a degenerate optimum of auto-catalytic cycles, and b) the set of targets for investigations of the origin of the common metabolic core should be significantly extended. Nature Publishing Group 2015-01-26 /pmc/articles/PMC4306138/ /pubmed/25620471 http://dx.doi.org/10.1038/srep08009 Text en Copyright © 2015, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Article
Zubarev, Dmitry Yu
Rappoport, Dmitrij
Aspuru-Guzik, Alán
Uncertainty of Prebiotic Scenarios: The Case of the Non-Enzymatic Reverse Tricarboxylic Acid Cycle
title Uncertainty of Prebiotic Scenarios: The Case of the Non-Enzymatic Reverse Tricarboxylic Acid Cycle
title_full Uncertainty of Prebiotic Scenarios: The Case of the Non-Enzymatic Reverse Tricarboxylic Acid Cycle
title_fullStr Uncertainty of Prebiotic Scenarios: The Case of the Non-Enzymatic Reverse Tricarboxylic Acid Cycle
title_full_unstemmed Uncertainty of Prebiotic Scenarios: The Case of the Non-Enzymatic Reverse Tricarboxylic Acid Cycle
title_short Uncertainty of Prebiotic Scenarios: The Case of the Non-Enzymatic Reverse Tricarboxylic Acid Cycle
title_sort uncertainty of prebiotic scenarios: the case of the non-enzymatic reverse tricarboxylic acid cycle
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306138/
https://www.ncbi.nlm.nih.gov/pubmed/25620471
http://dx.doi.org/10.1038/srep08009
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