The Role of Flavonoids on Oxidative Stress in Epilepsy

Backgrounds. Oxidative stress can result from excessive free-radical production and it is likely implicated as a possible mechanism involved in the initiation and progression of epileptogenesis. Flavonoids can protect the brain from oxidative stress. In the central nervous system (CNS) several flavo...

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Detalles Bibliográficos
Autores principales: Diniz, Tâmara Coimbra, Silva, Juliane Cabral, de Lima-Saraiva, Sarah Raquel Gomes, Ribeiro, Fernanda Pires Rodrigues de Almeida, Pacheco, Alessandra Gomes Marques, de Freitas, Rivelilson Mendes, Quintans-Júnior, Lucindo José, Quintans, Jullyana de Souza Siqueira, Mendes, Rosemairy Luciane, Almeida, Jackson Roberto Guedes da Silva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306219/
https://www.ncbi.nlm.nih.gov/pubmed/25653736
http://dx.doi.org/10.1155/2015/171756
Descripción
Sumario:Backgrounds. Oxidative stress can result from excessive free-radical production and it is likely implicated as a possible mechanism involved in the initiation and progression of epileptogenesis. Flavonoids can protect the brain from oxidative stress. In the central nervous system (CNS) several flavonoids bind to the benzodiazepine site on the GABA(A)-receptor resulting in anticonvulsive effects. Objective. This review provides an overview about the role of flavonoids in oxidative stress in epilepsy. The mechanism of action of flavonoids and its relation to the chemical structure is also discussed. Results/Conclusions. There is evidence that suggests that flavonoids have potential for neuroprotection in epilepsy.

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