The Role of Flavonoids on Oxidative Stress in Epilepsy

Backgrounds. Oxidative stress can result from excessive free-radical production and it is likely implicated as a possible mechanism involved in the initiation and progression of epileptogenesis. Flavonoids can protect the brain from oxidative stress. In the central nervous system (CNS) several flavo...

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Autores principales: Diniz, Tâmara Coimbra, Silva, Juliane Cabral, de Lima-Saraiva, Sarah Raquel Gomes, Ribeiro, Fernanda Pires Rodrigues de Almeida, Pacheco, Alessandra Gomes Marques, de Freitas, Rivelilson Mendes, Quintans-Júnior, Lucindo José, Quintans, Jullyana de Souza Siqueira, Mendes, Rosemairy Luciane, Almeida, Jackson Roberto Guedes da Silva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306219/
https://www.ncbi.nlm.nih.gov/pubmed/25653736
http://dx.doi.org/10.1155/2015/171756
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author Diniz, Tâmara Coimbra
Silva, Juliane Cabral
de Lima-Saraiva, Sarah Raquel Gomes
Ribeiro, Fernanda Pires Rodrigues de Almeida
Pacheco, Alessandra Gomes Marques
de Freitas, Rivelilson Mendes
Quintans-Júnior, Lucindo José
Quintans, Jullyana de Souza Siqueira
Mendes, Rosemairy Luciane
Almeida, Jackson Roberto Guedes da Silva
author_facet Diniz, Tâmara Coimbra
Silva, Juliane Cabral
de Lima-Saraiva, Sarah Raquel Gomes
Ribeiro, Fernanda Pires Rodrigues de Almeida
Pacheco, Alessandra Gomes Marques
de Freitas, Rivelilson Mendes
Quintans-Júnior, Lucindo José
Quintans, Jullyana de Souza Siqueira
Mendes, Rosemairy Luciane
Almeida, Jackson Roberto Guedes da Silva
author_sort Diniz, Tâmara Coimbra
collection PubMed
description Backgrounds. Oxidative stress can result from excessive free-radical production and it is likely implicated as a possible mechanism involved in the initiation and progression of epileptogenesis. Flavonoids can protect the brain from oxidative stress. In the central nervous system (CNS) several flavonoids bind to the benzodiazepine site on the GABA(A)-receptor resulting in anticonvulsive effects. Objective. This review provides an overview about the role of flavonoids in oxidative stress in epilepsy. The mechanism of action of flavonoids and its relation to the chemical structure is also discussed. Results/Conclusions. There is evidence that suggests that flavonoids have potential for neuroprotection in epilepsy.
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spelling pubmed-43062192015-02-04 The Role of Flavonoids on Oxidative Stress in Epilepsy Diniz, Tâmara Coimbra Silva, Juliane Cabral de Lima-Saraiva, Sarah Raquel Gomes Ribeiro, Fernanda Pires Rodrigues de Almeida Pacheco, Alessandra Gomes Marques de Freitas, Rivelilson Mendes Quintans-Júnior, Lucindo José Quintans, Jullyana de Souza Siqueira Mendes, Rosemairy Luciane Almeida, Jackson Roberto Guedes da Silva Oxid Med Cell Longev Review Article Backgrounds. Oxidative stress can result from excessive free-radical production and it is likely implicated as a possible mechanism involved in the initiation and progression of epileptogenesis. Flavonoids can protect the brain from oxidative stress. In the central nervous system (CNS) several flavonoids bind to the benzodiazepine site on the GABA(A)-receptor resulting in anticonvulsive effects. Objective. This review provides an overview about the role of flavonoids in oxidative stress in epilepsy. The mechanism of action of flavonoids and its relation to the chemical structure is also discussed. Results/Conclusions. There is evidence that suggests that flavonoids have potential for neuroprotection in epilepsy. Hindawi Publishing Corporation 2015 2015-01-11 /pmc/articles/PMC4306219/ /pubmed/25653736 http://dx.doi.org/10.1155/2015/171756 Text en Copyright © 2015 Tâmara Coimbra Diniz et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Diniz, Tâmara Coimbra
Silva, Juliane Cabral
de Lima-Saraiva, Sarah Raquel Gomes
Ribeiro, Fernanda Pires Rodrigues de Almeida
Pacheco, Alessandra Gomes Marques
de Freitas, Rivelilson Mendes
Quintans-Júnior, Lucindo José
Quintans, Jullyana de Souza Siqueira
Mendes, Rosemairy Luciane
Almeida, Jackson Roberto Guedes da Silva
The Role of Flavonoids on Oxidative Stress in Epilepsy
title The Role of Flavonoids on Oxidative Stress in Epilepsy
title_full The Role of Flavonoids on Oxidative Stress in Epilepsy
title_fullStr The Role of Flavonoids on Oxidative Stress in Epilepsy
title_full_unstemmed The Role of Flavonoids on Oxidative Stress in Epilepsy
title_short The Role of Flavonoids on Oxidative Stress in Epilepsy
title_sort role of flavonoids on oxidative stress in epilepsy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306219/
https://www.ncbi.nlm.nih.gov/pubmed/25653736
http://dx.doi.org/10.1155/2015/171756
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