A Case of Concurrent MPO-/PR3-Negative ANCA-Associated Glomerulonephritis and Membranous Glomerulopathy

We report a case in which antineutrophil cytoplasmic antibody- (ANCA-) associated glomerulonephritis and membranous glomerulopathy (MGN) were detected concurrently. The patient showed rapidly progressive renal deterioration. A renal biopsy showed crescentic glomerulonephritis, together with marked t...

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Autores principales: Nakada, Yasuyuki, Tsuboi, Nobuo, Takahashi, Yasuto, Yoshida, Hiraku, Hara, Yoriko, Okonogi, Hideo, Kawamura, Tetsuya, Arimura, Yoshihiro, Yokoo, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306403/
https://www.ncbi.nlm.nih.gov/pubmed/25648906
http://dx.doi.org/10.1155/2015/316863
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author Nakada, Yasuyuki
Tsuboi, Nobuo
Takahashi, Yasuto
Yoshida, Hiraku
Hara, Yoriko
Okonogi, Hideo
Kawamura, Tetsuya
Arimura, Yoshihiro
Yokoo, Takashi
author_facet Nakada, Yasuyuki
Tsuboi, Nobuo
Takahashi, Yasuto
Yoshida, Hiraku
Hara, Yoriko
Okonogi, Hideo
Kawamura, Tetsuya
Arimura, Yoshihiro
Yokoo, Takashi
author_sort Nakada, Yasuyuki
collection PubMed
description We report a case in which antineutrophil cytoplasmic antibody- (ANCA-) associated glomerulonephritis and membranous glomerulopathy (MGN) were detected concurrently. The patient showed rapidly progressive renal deterioration. A renal biopsy showed crescentic glomerulonephritis, together with marked thickening and spike and bubbling formations in the glomerular basement membranes. Indirect immunofluorescence examination of the patient's neutrophils showed a perinuclear pattern. Enzyme-linked immunosorbent assays revealed that the ANCA in this case did not target myeloperoxidase (MPO) or proteinase 3 (PR3) but bactericidal-/permeability-increasing protein, elastase, and lysosome. The relationship between these two etiologically distinct entities, MPO-/PR3-negative ANCA-associated glomerulonephritis and MGN, remains unclear.
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spelling pubmed-43064032015-02-03 A Case of Concurrent MPO-/PR3-Negative ANCA-Associated Glomerulonephritis and Membranous Glomerulopathy Nakada, Yasuyuki Tsuboi, Nobuo Takahashi, Yasuto Yoshida, Hiraku Hara, Yoriko Okonogi, Hideo Kawamura, Tetsuya Arimura, Yoshihiro Yokoo, Takashi Case Rep Nephrol Case Report We report a case in which antineutrophil cytoplasmic antibody- (ANCA-) associated glomerulonephritis and membranous glomerulopathy (MGN) were detected concurrently. The patient showed rapidly progressive renal deterioration. A renal biopsy showed crescentic glomerulonephritis, together with marked thickening and spike and bubbling formations in the glomerular basement membranes. Indirect immunofluorescence examination of the patient's neutrophils showed a perinuclear pattern. Enzyme-linked immunosorbent assays revealed that the ANCA in this case did not target myeloperoxidase (MPO) or proteinase 3 (PR3) but bactericidal-/permeability-increasing protein, elastase, and lysosome. The relationship between these two etiologically distinct entities, MPO-/PR3-negative ANCA-associated glomerulonephritis and MGN, remains unclear. Hindawi Publishing Corporation 2015 2015-01-08 /pmc/articles/PMC4306403/ /pubmed/25648906 http://dx.doi.org/10.1155/2015/316863 Text en Copyright © 2015 Yasuyuki Nakada et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Nakada, Yasuyuki
Tsuboi, Nobuo
Takahashi, Yasuto
Yoshida, Hiraku
Hara, Yoriko
Okonogi, Hideo
Kawamura, Tetsuya
Arimura, Yoshihiro
Yokoo, Takashi
A Case of Concurrent MPO-/PR3-Negative ANCA-Associated Glomerulonephritis and Membranous Glomerulopathy
title A Case of Concurrent MPO-/PR3-Negative ANCA-Associated Glomerulonephritis and Membranous Glomerulopathy
title_full A Case of Concurrent MPO-/PR3-Negative ANCA-Associated Glomerulonephritis and Membranous Glomerulopathy
title_fullStr A Case of Concurrent MPO-/PR3-Negative ANCA-Associated Glomerulonephritis and Membranous Glomerulopathy
title_full_unstemmed A Case of Concurrent MPO-/PR3-Negative ANCA-Associated Glomerulonephritis and Membranous Glomerulopathy
title_short A Case of Concurrent MPO-/PR3-Negative ANCA-Associated Glomerulonephritis and Membranous Glomerulopathy
title_sort case of concurrent mpo-/pr3-negative anca-associated glomerulonephritis and membranous glomerulopathy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306403/
https://www.ncbi.nlm.nih.gov/pubmed/25648906
http://dx.doi.org/10.1155/2015/316863
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