Optical Coherence Tomography Identifies Lower Labial Salivary Gland Surface Density in Cystic Fibrosis

The labial minor salivary glands (LSGs) are easily accessible mucus-secreting structures of the alimentary tract that may provide new information on the basis of gastrointestinal complications of cystic fibrosis (CF). It was shown that they are destructed in the course of cystic fibrosis. We employe...

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Autores principales: Nowak, Jan K., Grulkowski, Ireneusz, Karnowski, Karol, Wojtkowski, Maciej, Walkowiak, Jaroslaw
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306485/
https://www.ncbi.nlm.nih.gov/pubmed/25622042
http://dx.doi.org/10.1371/journal.pone.0117517
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author Nowak, Jan K.
Grulkowski, Ireneusz
Karnowski, Karol
Wojtkowski, Maciej
Walkowiak, Jaroslaw
author_facet Nowak, Jan K.
Grulkowski, Ireneusz
Karnowski, Karol
Wojtkowski, Maciej
Walkowiak, Jaroslaw
author_sort Nowak, Jan K.
collection PubMed
description The labial minor salivary glands (LSGs) are easily accessible mucus-secreting structures of the alimentary tract that may provide new information on the basis of gastrointestinal complications of cystic fibrosis (CF). It was shown that they are destructed in the course of cystic fibrosis. We employed wide-field, micrometer resolution in vivo optical coherence tomography to assess the surface density of LSGs in 18 patients with CF and 18 healthy subjects. The median LSGs’ surface densities in CF patients, and in the control group were 4.32 glands/cm(2) and 6.58 glands/cm(2), respectively (p = 0.006; Mann-Whitney U test). A lower LSG surface density is a previously unrecognized CF-related pathology of the alimentary tract.
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spelling pubmed-43064852015-01-30 Optical Coherence Tomography Identifies Lower Labial Salivary Gland Surface Density in Cystic Fibrosis Nowak, Jan K. Grulkowski, Ireneusz Karnowski, Karol Wojtkowski, Maciej Walkowiak, Jaroslaw PLoS One Research Article The labial minor salivary glands (LSGs) are easily accessible mucus-secreting structures of the alimentary tract that may provide new information on the basis of gastrointestinal complications of cystic fibrosis (CF). It was shown that they are destructed in the course of cystic fibrosis. We employed wide-field, micrometer resolution in vivo optical coherence tomography to assess the surface density of LSGs in 18 patients with CF and 18 healthy subjects. The median LSGs’ surface densities in CF patients, and in the control group were 4.32 glands/cm(2) and 6.58 glands/cm(2), respectively (p = 0.006; Mann-Whitney U test). A lower LSG surface density is a previously unrecognized CF-related pathology of the alimentary tract. Public Library of Science 2015-01-26 /pmc/articles/PMC4306485/ /pubmed/25622042 http://dx.doi.org/10.1371/journal.pone.0117517 Text en © 2015 Nowak et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Nowak, Jan K.
Grulkowski, Ireneusz
Karnowski, Karol
Wojtkowski, Maciej
Walkowiak, Jaroslaw
Optical Coherence Tomography Identifies Lower Labial Salivary Gland Surface Density in Cystic Fibrosis
title Optical Coherence Tomography Identifies Lower Labial Salivary Gland Surface Density in Cystic Fibrosis
title_full Optical Coherence Tomography Identifies Lower Labial Salivary Gland Surface Density in Cystic Fibrosis
title_fullStr Optical Coherence Tomography Identifies Lower Labial Salivary Gland Surface Density in Cystic Fibrosis
title_full_unstemmed Optical Coherence Tomography Identifies Lower Labial Salivary Gland Surface Density in Cystic Fibrosis
title_short Optical Coherence Tomography Identifies Lower Labial Salivary Gland Surface Density in Cystic Fibrosis
title_sort optical coherence tomography identifies lower labial salivary gland surface density in cystic fibrosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306485/
https://www.ncbi.nlm.nih.gov/pubmed/25622042
http://dx.doi.org/10.1371/journal.pone.0117517
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