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Evolution Alters the Enzymatic Reaction Coordinate of Dihydrofolate Reductase
[Image: see text] How evolution has affected enzyme function is a topic of great interest in the field of biophysical chemistry. Evolutionary changes from Escherichia coli dihydrofolate reductase (ecDHFR) to human dihydrofolate reductase (hsDHFR) have resulted in increased catalytic efficiency and a...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306496/ https://www.ncbi.nlm.nih.gov/pubmed/25369552 http://dx.doi.org/10.1021/jp506373q |