New Compstatin Peptides Containing N-Terminal Extensions and Non-Natural Amino Acids Exhibit Potent Complement Inhibition and Improved Solubility Characteristics

[Image: see text] Compstatin peptides are complement inhibitors that bind and inhibit cleavage of complement C3. Peptide binding is enhanced by hydrophobic interactions; however, poor solubility promotes aggregation in aqueous environments. We have designed new compstatin peptides derived from the W...

Descripción completa

Detalles Bibliográficos
Autores principales: Gorham, Ronald D., Forest, David L., Khoury, George A., Smadbeck, James, Beecher, Consuelo N., Healy, Evangeline D., Tamamis, Phanourios, Archontis, Georgios, Larive, Cynthia K., Floudas, Christodoulos A., Radeke, Monte J., Johnson, Lincoln V., Morikis, Dimitrios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306506/
https://www.ncbi.nlm.nih.gov/pubmed/25494040
http://dx.doi.org/10.1021/jm501345y

Ejemplares similares

Ejemplares similares