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Proteome-wide analysis of human disease mutations in short linear motifs: neglected players in cancer?
Disease mutations are traditionally thought to impair protein functionality by disrupting the folded globular structure of proteins. However, 22% of human disease mutations occur in natively unstructured segments of proteins known as intrinsically disordered regions (IDRs). This therefore implicates...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306509/ https://www.ncbi.nlm.nih.gov/pubmed/25057855 http://dx.doi.org/10.1039/c4mb00290c |