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Repositioning Proton Pump Inhibitors as Anticancer Drugs by Targeting the Thioesterase Domain of Human Fatty Acid Synthase

[Image: see text] Fatty acid synthase (FASN), the enzyme responsible for de novo synthesis of free fatty acids, is up-regulated in many cancers. FASN is essential for cancer cell survival and contributes to drug resistance and poor prognosis. However, it is not expressed in most nonlipogenic normal...

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Detalles Bibliográficos
Autores principales:	Fako, Valerie E., Wu, Xi, Pflug, Beth, Liu, Jing-Yuan, Zhang, Jian-Ting
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306520/ https://www.ncbi.nlm.nih.gov/pubmed/25513712 http://dx.doi.org/10.1021/jm501543u

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