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Microbiota Controls the Homeostasis of Glial Cells in the Gut Lamina Propria

The intrinsic neural networks of the gastrointestinal tract are derived from dedicated neural crest progenitors that colonize the gut during embryogenesis and give rise to enteric neurons and glia. Here, we study how an essential subpopulation of enteric glial cells (EGCs) residing within the intest...

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Autores principales: Kabouridis, Panagiotis S., Lasrado, Reena, McCallum, Sarah, Chng, Song Hui, Snippert, Hugo J., Clevers, Hans, Pettersson, Sven, Pachnis, Vassilis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306542/
https://www.ncbi.nlm.nih.gov/pubmed/25578362
http://dx.doi.org/10.1016/j.neuron.2014.12.037
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author Kabouridis, Panagiotis S.
Lasrado, Reena
McCallum, Sarah
Chng, Song Hui
Snippert, Hugo J.
Clevers, Hans
Pettersson, Sven
Pachnis, Vassilis
author_facet Kabouridis, Panagiotis S.
Lasrado, Reena
McCallum, Sarah
Chng, Song Hui
Snippert, Hugo J.
Clevers, Hans
Pettersson, Sven
Pachnis, Vassilis
author_sort Kabouridis, Panagiotis S.
collection PubMed
description The intrinsic neural networks of the gastrointestinal tract are derived from dedicated neural crest progenitors that colonize the gut during embryogenesis and give rise to enteric neurons and glia. Here, we study how an essential subpopulation of enteric glial cells (EGCs) residing within the intestinal mucosa is integrated into the dynamic microenvironment of the alimentary tract. We find that under normal conditions colonization of the lamina propria by glial cells commences during early postnatal stages but reaches steady-state levels after weaning. By employing genetic lineage tracing, we provide evidence that in adult mice the network of mucosal EGCs is continuously renewed by incoming glial cells originating in the plexi of the gut wall. Finally, we demonstrate that both the initial colonization and homeostasis of glial cells in the intestinal mucosa are regulated by the indigenous gut microbiota.
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spelling pubmed-43065422015-01-28 Microbiota Controls the Homeostasis of Glial Cells in the Gut Lamina Propria Kabouridis, Panagiotis S. Lasrado, Reena McCallum, Sarah Chng, Song Hui Snippert, Hugo J. Clevers, Hans Pettersson, Sven Pachnis, Vassilis Neuron Report The intrinsic neural networks of the gastrointestinal tract are derived from dedicated neural crest progenitors that colonize the gut during embryogenesis and give rise to enteric neurons and glia. Here, we study how an essential subpopulation of enteric glial cells (EGCs) residing within the intestinal mucosa is integrated into the dynamic microenvironment of the alimentary tract. We find that under normal conditions colonization of the lamina propria by glial cells commences during early postnatal stages but reaches steady-state levels after weaning. By employing genetic lineage tracing, we provide evidence that in adult mice the network of mucosal EGCs is continuously renewed by incoming glial cells originating in the plexi of the gut wall. Finally, we demonstrate that both the initial colonization and homeostasis of glial cells in the intestinal mucosa are regulated by the indigenous gut microbiota. Cell Press 2015-01-21 /pmc/articles/PMC4306542/ /pubmed/25578362 http://dx.doi.org/10.1016/j.neuron.2014.12.037 Text en © 2015 Medical Research Council. Published by Elsevier Inc. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Report
Kabouridis, Panagiotis S.
Lasrado, Reena
McCallum, Sarah
Chng, Song Hui
Snippert, Hugo J.
Clevers, Hans
Pettersson, Sven
Pachnis, Vassilis
Microbiota Controls the Homeostasis of Glial Cells in the Gut Lamina Propria
title Microbiota Controls the Homeostasis of Glial Cells in the Gut Lamina Propria
title_full Microbiota Controls the Homeostasis of Glial Cells in the Gut Lamina Propria
title_fullStr Microbiota Controls the Homeostasis of Glial Cells in the Gut Lamina Propria
title_full_unstemmed Microbiota Controls the Homeostasis of Glial Cells in the Gut Lamina Propria
title_short Microbiota Controls the Homeostasis of Glial Cells in the Gut Lamina Propria
title_sort microbiota controls the homeostasis of glial cells in the gut lamina propria
topic Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306542/
https://www.ncbi.nlm.nih.gov/pubmed/25578362
http://dx.doi.org/10.1016/j.neuron.2014.12.037
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