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Performance of Genotype Imputation for Low Frequency and Rare Variants from the 1000 Genomes

Genotype imputation is now routinely applied in genome-wide association studies (GWAS) and meta-analyses. However, most of the imputations have been run using HapMap samples as reference, imputation of low frequency and rare variants (minor allele frequency (MAF) < 5%) are not systemically assess...

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Detalles Bibliográficos
Autores principales:	Zheng, Hou-Feng, Rong, Jing-Jing, Liu, Ming, Han, Fang, Zhang, Xing-Wei, Richards, J. Brent, Wang, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306552/ https://www.ncbi.nlm.nih.gov/pubmed/25621886 http://dx.doi.org/10.1371/journal.pone.0116487

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