MitoBlue: A Nontoxic and Photostable Blue-Emitting Dye That Selectively Labels Functional Mitochondria

[Image: see text] We report the discovery of a fluorogenic dye, N(1),N(3)-di(2-aminidonaphthalen-6-yl) propane-1,3-diamine, MitoBlue, which selectively stains functional mitochondria while displaying low toxicity, bright blue emission, and high resistance to photobleaching. Additionally, we show tha...

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Autores principales: Sánchez, Mateo I., Martínez-Costas, José, Mascareñas, José L., Vázquez, M. Eugenio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306598/
https://www.ncbi.nlm.nih.gov/pubmed/25325672
http://dx.doi.org/10.1021/cb500552f
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author Sánchez, Mateo I.
Martínez-Costas, José
Mascareñas, José L.
Vázquez, M. Eugenio
author_facet Sánchez, Mateo I.
Martínez-Costas, José
Mascareñas, José L.
Vázquez, M. Eugenio
author_sort Sánchez, Mateo I.
collection PubMed
description [Image: see text] We report the discovery of a fluorogenic dye, N(1),N(3)-di(2-aminidonaphthalen-6-yl) propane-1,3-diamine, MitoBlue, which selectively stains functional mitochondria while displaying low toxicity, bright blue emission, and high resistance to photobleaching. Additionally, we show that a biotin-labeled MitoBlue derivative can be used as a handle for the delivery of streptavidin-tagged species to the mitochondria.
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spelling pubmed-43065982015-01-27 MitoBlue: A Nontoxic and Photostable Blue-Emitting Dye That Selectively Labels Functional Mitochondria Sánchez, Mateo I. Martínez-Costas, José Mascareñas, José L. Vázquez, M. Eugenio ACS Chem Biol [Image: see text] We report the discovery of a fluorogenic dye, N(1),N(3)-di(2-aminidonaphthalen-6-yl) propane-1,3-diamine, MitoBlue, which selectively stains functional mitochondria while displaying low toxicity, bright blue emission, and high resistance to photobleaching. Additionally, we show that a biotin-labeled MitoBlue derivative can be used as a handle for the delivery of streptavidin-tagged species to the mitochondria. American Chemical Society 2014-10-17 2014-12-19 /pmc/articles/PMC4306598/ /pubmed/25325672 http://dx.doi.org/10.1021/cb500552f Text en Copyright © 2014 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Sánchez, Mateo I.
Martínez-Costas, José
Mascareñas, José L.
Vázquez, M. Eugenio
MitoBlue: A Nontoxic and Photostable Blue-Emitting Dye That Selectively Labels Functional Mitochondria
title MitoBlue: A Nontoxic and Photostable Blue-Emitting Dye That Selectively Labels Functional Mitochondria
title_full MitoBlue: A Nontoxic and Photostable Blue-Emitting Dye That Selectively Labels Functional Mitochondria
title_fullStr MitoBlue: A Nontoxic and Photostable Blue-Emitting Dye That Selectively Labels Functional Mitochondria
title_full_unstemmed MitoBlue: A Nontoxic and Photostable Blue-Emitting Dye That Selectively Labels Functional Mitochondria
title_short MitoBlue: A Nontoxic and Photostable Blue-Emitting Dye That Selectively Labels Functional Mitochondria
title_sort mitoblue: a nontoxic and photostable blue-emitting dye that selectively labels functional mitochondria
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306598/
https://www.ncbi.nlm.nih.gov/pubmed/25325672
http://dx.doi.org/10.1021/cb500552f
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AT martinezcostasjose mitoblueanontoxicandphotostableblueemittingdyethatselectivelylabelsfunctionalmitochondria
AT mascarenasjosel mitoblueanontoxicandphotostableblueemittingdyethatselectivelylabelsfunctionalmitochondria
AT vazquezmeugenio mitoblueanontoxicandphotostableblueemittingdyethatselectivelylabelsfunctionalmitochondria

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