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Wake-active neurons across aging and neurodegeneration: a potential role for sleep disturbances in promoting disease

Sleep/wake disturbance is a feature of almost all common age-related neurodegenerative diseases. Although the reason for this is unknown, it is likely that this inability to maintain sleep and wake states is in large part due to declines in the number and function of wake-active neurons, populations...

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Detalles Bibliográficos
Autores principales: Stern, Anna L, Naidoo, Nirinjini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306674/
https://www.ncbi.nlm.nih.gov/pubmed/25635245
http://dx.doi.org/10.1186/s40064-014-0777-6
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author Stern, Anna L
Naidoo, Nirinjini
author_facet Stern, Anna L
Naidoo, Nirinjini
author_sort Stern, Anna L
collection PubMed
description Sleep/wake disturbance is a feature of almost all common age-related neurodegenerative diseases. Although the reason for this is unknown, it is likely that this inability to maintain sleep and wake states is in large part due to declines in the number and function of wake-active neurons, populations of cells that fire only during waking and are silent during sleep. Consistent with this, many of the brain regions that are most susceptible to neurodegeneration are those that are necessary for wake maintenance and alertness. In the present review, these wake-active populations are systematically assessed in terms of their observed pathology across aging and several neurodegenerative diseases, with implications for future research relating sleep and wake disturbances to aging and age-related neurodegeneration.
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spelling pubmed-43066742015-01-29 Wake-active neurons across aging and neurodegeneration: a potential role for sleep disturbances in promoting disease Stern, Anna L Naidoo, Nirinjini Springerplus Review Sleep/wake disturbance is a feature of almost all common age-related neurodegenerative diseases. Although the reason for this is unknown, it is likely that this inability to maintain sleep and wake states is in large part due to declines in the number and function of wake-active neurons, populations of cells that fire only during waking and are silent during sleep. Consistent with this, many of the brain regions that are most susceptible to neurodegeneration are those that are necessary for wake maintenance and alertness. In the present review, these wake-active populations are systematically assessed in terms of their observed pathology across aging and several neurodegenerative diseases, with implications for future research relating sleep and wake disturbances to aging and age-related neurodegeneration. Springer International Publishing 2015-01-17 /pmc/articles/PMC4306674/ /pubmed/25635245 http://dx.doi.org/10.1186/s40064-014-0777-6 Text en © Stern and Naidoo; licensee Springer. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Review
Stern, Anna L
Naidoo, Nirinjini
Wake-active neurons across aging and neurodegeneration: a potential role for sleep disturbances in promoting disease
title Wake-active neurons across aging and neurodegeneration: a potential role for sleep disturbances in promoting disease
title_full Wake-active neurons across aging and neurodegeneration: a potential role for sleep disturbances in promoting disease
title_fullStr Wake-active neurons across aging and neurodegeneration: a potential role for sleep disturbances in promoting disease
title_full_unstemmed Wake-active neurons across aging and neurodegeneration: a potential role for sleep disturbances in promoting disease
title_short Wake-active neurons across aging and neurodegeneration: a potential role for sleep disturbances in promoting disease
title_sort wake-active neurons across aging and neurodegeneration: a potential role for sleep disturbances in promoting disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306674/
https://www.ncbi.nlm.nih.gov/pubmed/25635245
http://dx.doi.org/10.1186/s40064-014-0777-6
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