Identification of a Novel Human Rhinovirus C Type by Antibody Capture VIDISCA-454

Causative agents for more than 30 percent of respiratory infections remain unidentified, suggesting that unknown respiratory pathogens might be involved. In this study, antibody capture VIDISCA-454 (virus discovery cDNA-AFLP combined with Roche 454 high-throughput sequencing) resulted in the discove...

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Detalles Bibliográficos
Autores principales: Jazaeri Farsani, Seyed Mohammad, Oude Munnink, Bas B., Canuti, Marta, Deijs, Martin, Cotten, Matthew, Jebbink, Maarten F., Verhoeven, Joost, Kellam, Paul, Loens, Katherine, Goossens, Herman, Ieven, Margareta, van der Hoek, Lia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306836/
https://www.ncbi.nlm.nih.gov/pubmed/25606972
http://dx.doi.org/10.3390/v7010239
Descripción
Sumario:Causative agents for more than 30 percent of respiratory infections remain unidentified, suggesting that unknown respiratory pathogens might be involved. In this study, antibody capture VIDISCA-454 (virus discovery cDNA-AFLP combined with Roche 454 high-throughput sequencing) resulted in the discovery of a novel type of rhinovirus C (RV-C). The virus has an RNA genome of at least 7054 nt and carries the characteristics of rhinovirus C species. The gene encoding viral protein 1, which is used for typing, has only 81% nucleotide sequence identity with the closest known RV-C type, and, therefore, the virus represents the first member of a novel type, named RV-C54.

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