Identification of a Novel Human Rhinovirus C Type by Antibody Capture VIDISCA-454

Causative agents for more than 30 percent of respiratory infections remain unidentified, suggesting that unknown respiratory pathogens might be involved. In this study, antibody capture VIDISCA-454 (virus discovery cDNA-AFLP combined with Roche 454 high-throughput sequencing) resulted in the discove...

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Autores principales: Jazaeri Farsani, Seyed Mohammad, Oude Munnink, Bas B., Canuti, Marta, Deijs, Martin, Cotten, Matthew, Jebbink, Maarten F., Verhoeven, Joost, Kellam, Paul, Loens, Katherine, Goossens, Herman, Ieven, Margareta, van der Hoek, Lia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306836/
https://www.ncbi.nlm.nih.gov/pubmed/25606972
http://dx.doi.org/10.3390/v7010239
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author Jazaeri Farsani, Seyed Mohammad
Oude Munnink, Bas B.
Canuti, Marta
Deijs, Martin
Cotten, Matthew
Jebbink, Maarten F.
Verhoeven, Joost
Kellam, Paul
Loens, Katherine
Goossens, Herman
Ieven, Margareta
van der Hoek, Lia
author_facet Jazaeri Farsani, Seyed Mohammad
Oude Munnink, Bas B.
Canuti, Marta
Deijs, Martin
Cotten, Matthew
Jebbink, Maarten F.
Verhoeven, Joost
Kellam, Paul
Loens, Katherine
Goossens, Herman
Ieven, Margareta
van der Hoek, Lia
author_sort Jazaeri Farsani, Seyed Mohammad
collection PubMed
description Causative agents for more than 30 percent of respiratory infections remain unidentified, suggesting that unknown respiratory pathogens might be involved. In this study, antibody capture VIDISCA-454 (virus discovery cDNA-AFLP combined with Roche 454 high-throughput sequencing) resulted in the discovery of a novel type of rhinovirus C (RV-C). The virus has an RNA genome of at least 7054 nt and carries the characteristics of rhinovirus C species. The gene encoding viral protein 1, which is used for typing, has only 81% nucleotide sequence identity with the closest known RV-C type, and, therefore, the virus represents the first member of a novel type, named RV-C54.
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spelling pubmed-43068362015-02-02 Identification of a Novel Human Rhinovirus C Type by Antibody Capture VIDISCA-454 Jazaeri Farsani, Seyed Mohammad Oude Munnink, Bas B. Canuti, Marta Deijs, Martin Cotten, Matthew Jebbink, Maarten F. Verhoeven, Joost Kellam, Paul Loens, Katherine Goossens, Herman Ieven, Margareta van der Hoek, Lia Viruses Article Causative agents for more than 30 percent of respiratory infections remain unidentified, suggesting that unknown respiratory pathogens might be involved. In this study, antibody capture VIDISCA-454 (virus discovery cDNA-AFLP combined with Roche 454 high-throughput sequencing) resulted in the discovery of a novel type of rhinovirus C (RV-C). The virus has an RNA genome of at least 7054 nt and carries the characteristics of rhinovirus C species. The gene encoding viral protein 1, which is used for typing, has only 81% nucleotide sequence identity with the closest known RV-C type, and, therefore, the virus represents the first member of a novel type, named RV-C54. MDPI 2015-01-19 /pmc/articles/PMC4306836/ /pubmed/25606972 http://dx.doi.org/10.3390/v7010239 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jazaeri Farsani, Seyed Mohammad
Oude Munnink, Bas B.
Canuti, Marta
Deijs, Martin
Cotten, Matthew
Jebbink, Maarten F.
Verhoeven, Joost
Kellam, Paul
Loens, Katherine
Goossens, Herman
Ieven, Margareta
van der Hoek, Lia
Identification of a Novel Human Rhinovirus C Type by Antibody Capture VIDISCA-454
title Identification of a Novel Human Rhinovirus C Type by Antibody Capture VIDISCA-454
title_full Identification of a Novel Human Rhinovirus C Type by Antibody Capture VIDISCA-454
title_fullStr Identification of a Novel Human Rhinovirus C Type by Antibody Capture VIDISCA-454
title_full_unstemmed Identification of a Novel Human Rhinovirus C Type by Antibody Capture VIDISCA-454
title_short Identification of a Novel Human Rhinovirus C Type by Antibody Capture VIDISCA-454
title_sort identification of a novel human rhinovirus c type by antibody capture vidisca-454
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306836/
https://www.ncbi.nlm.nih.gov/pubmed/25606972
http://dx.doi.org/10.3390/v7010239
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