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The Association between Hantavirus Infection and Selenium Deficiency in Mainland China

Hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses and transmitted by rodents is a significant public health problem in China, and occurs more frequently in selenium-deficient regions. To study the role of selenium concentration in HFRS incidence we used a multidisciplinary approach...

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Autores principales: Fang, Li-Qun, Goeijenbier, Marco, Zuo, Shu-Qing, Wang, Li-Ping, Liang, Song, Klein, Sabra L., Li, Xin-Lou, Liu, Kun, Liang, Lu, Gong, Peng, Glass, Gregory E., van Gorp, Eric, Richardus, Jan H., Ma, Jia-Qi, Cao, Wu-Chun, de Vlas, Sake J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306842/
https://www.ncbi.nlm.nih.gov/pubmed/25609306
http://dx.doi.org/10.3390/v7010333
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author Fang, Li-Qun
Goeijenbier, Marco
Zuo, Shu-Qing
Wang, Li-Ping
Liang, Song
Klein, Sabra L.
Li, Xin-Lou
Liu, Kun
Liang, Lu
Gong, Peng
Glass, Gregory E.
van Gorp, Eric
Richardus, Jan H.
Ma, Jia-Qi
Cao, Wu-Chun
de Vlas, Sake J.
author_facet Fang, Li-Qun
Goeijenbier, Marco
Zuo, Shu-Qing
Wang, Li-Ping
Liang, Song
Klein, Sabra L.
Li, Xin-Lou
Liu, Kun
Liang, Lu
Gong, Peng
Glass, Gregory E.
van Gorp, Eric
Richardus, Jan H.
Ma, Jia-Qi
Cao, Wu-Chun
de Vlas, Sake J.
author_sort Fang, Li-Qun
collection PubMed
description Hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses and transmitted by rodents is a significant public health problem in China, and occurs more frequently in selenium-deficient regions. To study the role of selenium concentration in HFRS incidence we used a multidisciplinary approach combining ecological analysis with preliminary experimental data. The incidence of HFRS in humans was about six times higher in severe selenium-deficient and double in moderate deficient areas compared to non-deficient areas. This association became statistically stronger after correction for other significant environment-related factors (low elevation, few grasslands, or an abundance of forests) and was independent of geographical scale by separate analyses for different climate regions. A case-control study of HFRS patients admitted to the hospital revealed increased activity and plasma levels of selenium binding proteins while selenium supplementation in vitro decreased viral replication in an endothelial cell model after infection with a low multiplicity of infection (MOI). Viral replication with a higher MOI was not affected by selenium supplementation. Our findings indicate that selenium deficiency may contribute to an increased prevalence of hantavirus infections in both humans and rodents. Future studies are needed to further examine the exact mechanism behind this observation before selenium supplementation in deficient areas could be implemented for HFRS prevention.
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spelling pubmed-43068422015-02-02 The Association between Hantavirus Infection and Selenium Deficiency in Mainland China Fang, Li-Qun Goeijenbier, Marco Zuo, Shu-Qing Wang, Li-Ping Liang, Song Klein, Sabra L. Li, Xin-Lou Liu, Kun Liang, Lu Gong, Peng Glass, Gregory E. van Gorp, Eric Richardus, Jan H. Ma, Jia-Qi Cao, Wu-Chun de Vlas, Sake J. Viruses Article Hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses and transmitted by rodents is a significant public health problem in China, and occurs more frequently in selenium-deficient regions. To study the role of selenium concentration in HFRS incidence we used a multidisciplinary approach combining ecological analysis with preliminary experimental data. The incidence of HFRS in humans was about six times higher in severe selenium-deficient and double in moderate deficient areas compared to non-deficient areas. This association became statistically stronger after correction for other significant environment-related factors (low elevation, few grasslands, or an abundance of forests) and was independent of geographical scale by separate analyses for different climate regions. A case-control study of HFRS patients admitted to the hospital revealed increased activity and plasma levels of selenium binding proteins while selenium supplementation in vitro decreased viral replication in an endothelial cell model after infection with a low multiplicity of infection (MOI). Viral replication with a higher MOI was not affected by selenium supplementation. Our findings indicate that selenium deficiency may contribute to an increased prevalence of hantavirus infections in both humans and rodents. Future studies are needed to further examine the exact mechanism behind this observation before selenium supplementation in deficient areas could be implemented for HFRS prevention. MDPI 2015-01-20 /pmc/articles/PMC4306842/ /pubmed/25609306 http://dx.doi.org/10.3390/v7010333 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fang, Li-Qun
Goeijenbier, Marco
Zuo, Shu-Qing
Wang, Li-Ping
Liang, Song
Klein, Sabra L.
Li, Xin-Lou
Liu, Kun
Liang, Lu
Gong, Peng
Glass, Gregory E.
van Gorp, Eric
Richardus, Jan H.
Ma, Jia-Qi
Cao, Wu-Chun
de Vlas, Sake J.
The Association between Hantavirus Infection and Selenium Deficiency in Mainland China
title The Association between Hantavirus Infection and Selenium Deficiency in Mainland China
title_full The Association between Hantavirus Infection and Selenium Deficiency in Mainland China
title_fullStr The Association between Hantavirus Infection and Selenium Deficiency in Mainland China
title_full_unstemmed The Association between Hantavirus Infection and Selenium Deficiency in Mainland China
title_short The Association between Hantavirus Infection and Selenium Deficiency in Mainland China
title_sort association between hantavirus infection and selenium deficiency in mainland china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306842/
https://www.ncbi.nlm.nih.gov/pubmed/25609306
http://dx.doi.org/10.3390/v7010333
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