Cargando…

Short-Term Variability and Predictors of Urinary Pentachlorophenol Levels in Ohio Preschool Children

Pentachlorophenol (PCP) is a persistent and ubiquitous environmental contaminant. No published data exist on the temporal variability or important predictors of urinary PCP concentrations in young children. In this further analysis of study data, we have examined the associations between selected so...

Descripción completa

Detalles Bibliográficos
Autores principales: Morgan, Marsha, Jones, Paul, Sobus, Jon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306893/
https://www.ncbi.nlm.nih.gov/pubmed/25594782
http://dx.doi.org/10.3390/ijerph120100800
_version_ 1782354378297966592
author Morgan, Marsha
Jones, Paul
Sobus, Jon
author_facet Morgan, Marsha
Jones, Paul
Sobus, Jon
author_sort Morgan, Marsha
collection PubMed
description Pentachlorophenol (PCP) is a persistent and ubiquitous environmental contaminant. No published data exist on the temporal variability or important predictors of urinary PCP concentrations in young children. In this further analysis of study data, we have examined the associations between selected sociodemographic or lifestyle factors and urinary PCP concentrations in 115 preschool children over a 48-h period and assessed the 48-hour variability of urinary PCP levels in a subset of 15 children. Monitoring was performed at 115 homes and 16 daycares in Ohio (USA) in 2001. Questionnaires/diaries and spot urine samples were collected from each child. The median urinary PCP level was 0.8 ng/mL (range < 0.2–23.8 ng/mL). The intraclass correlation coefficient for urinary PCP was 0.42, which indicates fairly low reliability for a single sample over a 48-h period. In a multiple regression model, age of home and ln(creatinine levels) were significant predictors and sampling season, time spent outside, and pet ownership were marginally significant predictors of ln(urinary PCP levels), collectively explaining 29% of the variability of PCP in urine. To adequately assess short-term exposures of children to PCP, several spot urine measurements are likely needed as well as information regarding residence age, seasonality, time spent outdoors, and pet ownership.
format Online
Article
Text
id pubmed-4306893
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-43068932015-02-02 Short-Term Variability and Predictors of Urinary Pentachlorophenol Levels in Ohio Preschool Children Morgan, Marsha Jones, Paul Sobus, Jon Int J Environ Res Public Health Article Pentachlorophenol (PCP) is a persistent and ubiquitous environmental contaminant. No published data exist on the temporal variability or important predictors of urinary PCP concentrations in young children. In this further analysis of study data, we have examined the associations between selected sociodemographic or lifestyle factors and urinary PCP concentrations in 115 preschool children over a 48-h period and assessed the 48-hour variability of urinary PCP levels in a subset of 15 children. Monitoring was performed at 115 homes and 16 daycares in Ohio (USA) in 2001. Questionnaires/diaries and spot urine samples were collected from each child. The median urinary PCP level was 0.8 ng/mL (range < 0.2–23.8 ng/mL). The intraclass correlation coefficient for urinary PCP was 0.42, which indicates fairly low reliability for a single sample over a 48-h period. In a multiple regression model, age of home and ln(creatinine levels) were significant predictors and sampling season, time spent outside, and pet ownership were marginally significant predictors of ln(urinary PCP levels), collectively explaining 29% of the variability of PCP in urine. To adequately assess short-term exposures of children to PCP, several spot urine measurements are likely needed as well as information regarding residence age, seasonality, time spent outdoors, and pet ownership. MDPI 2015-01-14 2015-01 /pmc/articles/PMC4306893/ /pubmed/25594782 http://dx.doi.org/10.3390/ijerph120100800 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Morgan, Marsha
Jones, Paul
Sobus, Jon
Short-Term Variability and Predictors of Urinary Pentachlorophenol Levels in Ohio Preschool Children
title Short-Term Variability and Predictors of Urinary Pentachlorophenol Levels in Ohio Preschool Children
title_full Short-Term Variability and Predictors of Urinary Pentachlorophenol Levels in Ohio Preschool Children
title_fullStr Short-Term Variability and Predictors of Urinary Pentachlorophenol Levels in Ohio Preschool Children
title_full_unstemmed Short-Term Variability and Predictors of Urinary Pentachlorophenol Levels in Ohio Preschool Children
title_short Short-Term Variability and Predictors of Urinary Pentachlorophenol Levels in Ohio Preschool Children
title_sort short-term variability and predictors of urinary pentachlorophenol levels in ohio preschool children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306893/
https://www.ncbi.nlm.nih.gov/pubmed/25594782
http://dx.doi.org/10.3390/ijerph120100800
work_keys_str_mv AT morganmarsha shorttermvariabilityandpredictorsofurinarypentachlorophenollevelsinohiopreschoolchildren
AT jonespaul shorttermvariabilityandpredictorsofurinarypentachlorophenollevelsinohiopreschoolchildren
AT sobusjon shorttermvariabilityandpredictorsofurinarypentachlorophenollevelsinohiopreschoolchildren