New Ikarugamycin Derivatives with Antifungal and Antibacterial Properties from Streptomyces zhaozhouensis

A bioassay guided fractionation of the ethyl acetate extract from culture broths of the strain Streptomyces zhaozhouensis CA-185989 led to the isolation of three new polycyclic tetramic acid macrolactams (1–3) and four known compounds. All the new compounds were structurally related to the known Str...

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Autores principales: Lacret, Rodney, Oves-Costales, Daniel, Gómez, Cristina, Díaz, Caridad, de la Cruz, Mercedes, Pérez-Victoria, Ignacio, Vicente, Francisca, Genilloud, Olga, Reyes, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306928/
https://www.ncbi.nlm.nih.gov/pubmed/25551780
http://dx.doi.org/10.3390/md13010128
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author Lacret, Rodney
Oves-Costales, Daniel
Gómez, Cristina
Díaz, Caridad
de la Cruz, Mercedes
Pérez-Victoria, Ignacio
Vicente, Francisca
Genilloud, Olga
Reyes, Fernando
author_facet Lacret, Rodney
Oves-Costales, Daniel
Gómez, Cristina
Díaz, Caridad
de la Cruz, Mercedes
Pérez-Victoria, Ignacio
Vicente, Francisca
Genilloud, Olga
Reyes, Fernando
author_sort Lacret, Rodney
collection PubMed
description A bioassay guided fractionation of the ethyl acetate extract from culture broths of the strain Streptomyces zhaozhouensis CA-185989 led to the isolation of three new polycyclic tetramic acid macrolactams (1–3) and four known compounds. All the new compounds were structurally related to the known Streptomyces metabolite ikarugamycin (4). Their structural elucidation was accomplished using a combination of electrospray-time of flight mass spectrometry (ESI-TOF MS) and 1D and 2D NMR analyses. Compounds 1–3 showed antifungal activity against Aspergillus fumigatus, Candida albicans and antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).
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spelling pubmed-43069282015-02-02 New Ikarugamycin Derivatives with Antifungal and Antibacterial Properties from Streptomyces zhaozhouensis Lacret, Rodney Oves-Costales, Daniel Gómez, Cristina Díaz, Caridad de la Cruz, Mercedes Pérez-Victoria, Ignacio Vicente, Francisca Genilloud, Olga Reyes, Fernando Mar Drugs Article A bioassay guided fractionation of the ethyl acetate extract from culture broths of the strain Streptomyces zhaozhouensis CA-185989 led to the isolation of three new polycyclic tetramic acid macrolactams (1–3) and four known compounds. All the new compounds were structurally related to the known Streptomyces metabolite ikarugamycin (4). Their structural elucidation was accomplished using a combination of electrospray-time of flight mass spectrometry (ESI-TOF MS) and 1D and 2D NMR analyses. Compounds 1–3 showed antifungal activity against Aspergillus fumigatus, Candida albicans and antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). MDPI 2014-12-29 /pmc/articles/PMC4306928/ /pubmed/25551780 http://dx.doi.org/10.3390/md13010128 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lacret, Rodney
Oves-Costales, Daniel
Gómez, Cristina
Díaz, Caridad
de la Cruz, Mercedes
Pérez-Victoria, Ignacio
Vicente, Francisca
Genilloud, Olga
Reyes, Fernando
New Ikarugamycin Derivatives with Antifungal and Antibacterial Properties from Streptomyces zhaozhouensis
title New Ikarugamycin Derivatives with Antifungal and Antibacterial Properties from Streptomyces zhaozhouensis
title_full New Ikarugamycin Derivatives with Antifungal and Antibacterial Properties from Streptomyces zhaozhouensis
title_fullStr New Ikarugamycin Derivatives with Antifungal and Antibacterial Properties from Streptomyces zhaozhouensis
title_full_unstemmed New Ikarugamycin Derivatives with Antifungal and Antibacterial Properties from Streptomyces zhaozhouensis
title_short New Ikarugamycin Derivatives with Antifungal and Antibacterial Properties from Streptomyces zhaozhouensis
title_sort new ikarugamycin derivatives with antifungal and antibacterial properties from streptomyces zhaozhouensis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306928/
https://www.ncbi.nlm.nih.gov/pubmed/25551780
http://dx.doi.org/10.3390/md13010128
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