New Meroterpenoids from the Endophytic Fungus Aspergillus flavipes AIL8 Derived from the Mangrove Plant Acanthus ilicifolius

Four new meroterpenoids (2–5), along with three known analogues (1, 6, and 7) were isolated from mangrove plant Acanthus ilicifolius derived endophytic fungus Aspergillus flavipes. The structures of these compounds were elucidated by NMR and MS analysis, the configurations were assigned by CD data,...

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Autores principales: Bai, Zhi-Qiang, Lin, Xiuping, Wang, Junfeng, Zhou, Xuefeng, Liu, Juan, Yang, Bin, Yang, Xianwen, Liao, Shengrong, Wang, Lishu, Liu, Yonghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306934/
https://www.ncbi.nlm.nih.gov/pubmed/25574738
http://dx.doi.org/10.3390/md13010237
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author Bai, Zhi-Qiang
Lin, Xiuping
Wang, Junfeng
Zhou, Xuefeng
Liu, Juan
Yang, Bin
Yang, Xianwen
Liao, Shengrong
Wang, Lishu
Liu, Yonghong
author_facet Bai, Zhi-Qiang
Lin, Xiuping
Wang, Junfeng
Zhou, Xuefeng
Liu, Juan
Yang, Bin
Yang, Xianwen
Liao, Shengrong
Wang, Lishu
Liu, Yonghong
author_sort Bai, Zhi-Qiang
collection PubMed
description Four new meroterpenoids (2–5), along with three known analogues (1, 6, and 7) were isolated from mangrove plant Acanthus ilicifolius derived endophytic fungus Aspergillus flavipes. The structures of these compounds were elucidated by NMR and MS analysis, the configurations were assigned by CD data, and the stereochemistry of 1 was confirmed by X-ray crystallography analysis. A possible biogenetic pathway of compounds 1–7 was also proposed. All compounds were evaluated for antibacterial and cytotoxic activities.
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spelling pubmed-43069342015-02-02 New Meroterpenoids from the Endophytic Fungus Aspergillus flavipes AIL8 Derived from the Mangrove Plant Acanthus ilicifolius Bai, Zhi-Qiang Lin, Xiuping Wang, Junfeng Zhou, Xuefeng Liu, Juan Yang, Bin Yang, Xianwen Liao, Shengrong Wang, Lishu Liu, Yonghong Mar Drugs Article Four new meroterpenoids (2–5), along with three known analogues (1, 6, and 7) were isolated from mangrove plant Acanthus ilicifolius derived endophytic fungus Aspergillus flavipes. The structures of these compounds were elucidated by NMR and MS analysis, the configurations were assigned by CD data, and the stereochemistry of 1 was confirmed by X-ray crystallography analysis. A possible biogenetic pathway of compounds 1–7 was also proposed. All compounds were evaluated for antibacterial and cytotoxic activities. MDPI 2015-01-07 /pmc/articles/PMC4306934/ /pubmed/25574738 http://dx.doi.org/10.3390/md13010237 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bai, Zhi-Qiang
Lin, Xiuping
Wang, Junfeng
Zhou, Xuefeng
Liu, Juan
Yang, Bin
Yang, Xianwen
Liao, Shengrong
Wang, Lishu
Liu, Yonghong
New Meroterpenoids from the Endophytic Fungus Aspergillus flavipes AIL8 Derived from the Mangrove Plant Acanthus ilicifolius
title New Meroterpenoids from the Endophytic Fungus Aspergillus flavipes AIL8 Derived from the Mangrove Plant Acanthus ilicifolius
title_full New Meroterpenoids from the Endophytic Fungus Aspergillus flavipes AIL8 Derived from the Mangrove Plant Acanthus ilicifolius
title_fullStr New Meroterpenoids from the Endophytic Fungus Aspergillus flavipes AIL8 Derived from the Mangrove Plant Acanthus ilicifolius
title_full_unstemmed New Meroterpenoids from the Endophytic Fungus Aspergillus flavipes AIL8 Derived from the Mangrove Plant Acanthus ilicifolius
title_short New Meroterpenoids from the Endophytic Fungus Aspergillus flavipes AIL8 Derived from the Mangrove Plant Acanthus ilicifolius
title_sort new meroterpenoids from the endophytic fungus aspergillus flavipes ail8 derived from the mangrove plant acanthus ilicifolius
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306934/
https://www.ncbi.nlm.nih.gov/pubmed/25574738
http://dx.doi.org/10.3390/md13010237
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