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Penicibrocazines A–E, Five New Sulfide Diketopiperazines from the Marine-Derived Endophytic Fungus Penicillium brocae

Five new sulfide diketopiperazine derivatives, namely, penicibrocazines A–E (1–5), along with a known congener (6), were isolated and identified from the culture extract of Penicillium brocae MA-231, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. T...

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Detalles Bibliográficos
Autores principales: Meng, Ling-Hong, Zhang, Peng, Li, Xiao-Ming, Wang, Bin-Gui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306937/
https://www.ncbi.nlm.nih.gov/pubmed/25574740
http://dx.doi.org/10.3390/md13010276
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author Meng, Ling-Hong
Zhang, Peng
Li, Xiao-Ming
Wang, Bin-Gui
author_facet Meng, Ling-Hong
Zhang, Peng
Li, Xiao-Ming
Wang, Bin-Gui
author_sort Meng, Ling-Hong
collection PubMed
description Five new sulfide diketopiperazine derivatives, namely, penicibrocazines A–E (1–5), along with a known congener (6), were isolated and identified from the culture extract of Penicillium brocae MA-231, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of these compounds were elucidated by detailed interpretation of NMR and mass spectroscopic data and the structures of compounds 1 and 3 were confirmed by single-crystal X-ray diffraction analysis. All these compounds were examined for cytotoxic and antimicrobial activities. Compounds 2–6 exhibited antimicrobial activity against some of the tested strains with MIC values ranging from 0.25 to 64 μg/mL.
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spelling pubmed-43069372015-02-02 Penicibrocazines A–E, Five New Sulfide Diketopiperazines from the Marine-Derived Endophytic Fungus Penicillium brocae Meng, Ling-Hong Zhang, Peng Li, Xiao-Ming Wang, Bin-Gui Mar Drugs Article Five new sulfide diketopiperazine derivatives, namely, penicibrocazines A–E (1–5), along with a known congener (6), were isolated and identified from the culture extract of Penicillium brocae MA-231, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of these compounds were elucidated by detailed interpretation of NMR and mass spectroscopic data and the structures of compounds 1 and 3 were confirmed by single-crystal X-ray diffraction analysis. All these compounds were examined for cytotoxic and antimicrobial activities. Compounds 2–6 exhibited antimicrobial activity against some of the tested strains with MIC values ranging from 0.25 to 64 μg/mL. MDPI 2015-01-07 /pmc/articles/PMC4306937/ /pubmed/25574740 http://dx.doi.org/10.3390/md13010276 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Meng, Ling-Hong
Zhang, Peng
Li, Xiao-Ming
Wang, Bin-Gui
Penicibrocazines A–E, Five New Sulfide Diketopiperazines from the Marine-Derived Endophytic Fungus Penicillium brocae
title Penicibrocazines A–E, Five New Sulfide Diketopiperazines from the Marine-Derived Endophytic Fungus Penicillium brocae
title_full Penicibrocazines A–E, Five New Sulfide Diketopiperazines from the Marine-Derived Endophytic Fungus Penicillium brocae
title_fullStr Penicibrocazines A–E, Five New Sulfide Diketopiperazines from the Marine-Derived Endophytic Fungus Penicillium brocae
title_full_unstemmed Penicibrocazines A–E, Five New Sulfide Diketopiperazines from the Marine-Derived Endophytic Fungus Penicillium brocae
title_short Penicibrocazines A–E, Five New Sulfide Diketopiperazines from the Marine-Derived Endophytic Fungus Penicillium brocae
title_sort penicibrocazines a–e, five new sulfide diketopiperazines from the marine-derived endophytic fungus penicillium brocae
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306937/
https://www.ncbi.nlm.nih.gov/pubmed/25574740
http://dx.doi.org/10.3390/md13010276
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